#epithelia — Public Fediverse posts

@mechanobio
Interesting story where #actin and #keratin organisation are seen to alter differently depending on #polarity protein aPKCλ.
#cytoskeleton #epithelia #mechanics @mechanobiology

@mechanobio Towards an understanding of #epithelia 3D mechanical balance: a topic for which work is very much needed.
@mechanobiology

We also apply #SimuCell3D to the study of two morphogenetic problems: the formation and maintenance of #layered #epithelia and the cellular organization in a #pseudostratified epithelium.

🧵(7/9)

@mechanobio
Great preprint, where one can see #epithelia torn by pulling on them or by their internal #tension (generated by #myosin activity).

A slow pull (low strain rate) allows the monolayer to sustain much larger strain.

Finally, they show how #keratin intermediate filaments are key for these mechanical properties.

@JonFouchard @UlrichSchwarz @edouardhannezo

What controls dynamic #Epithelial-to-#Mesenchymal Transition of #cancer cells?

Peter ten Dijke Lab at LUMC Leiden identify #plasmamembrane #glycosphingolipid composition and expression of their biosynthesis enzymes as key determinants of dynamic #EMT and #malignant transformation in human #epithelia

https://www.embopress.org/doi/10.15252/embj.2021110553