#enhancers — Public Fediverse posts

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes.

#EndogenousRetroviruses #ERVs #MusD #VirusLikeParticles #TopologicallyAssociatingDomains #Enhancers #LimbDevelopment #Apoptosis #Dactylaplasia

https://www.nature.com/articles/s41588-025-02248-5

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes.

#EndogenousRetroviruses #ERVs #MusD #VirusLikeParticles #TopologicallyAssociatingDomains #Enhancers #LimbDevelopment #Apoptosis #Dactylaplasia

https://www.nature.com/articles/s41588-025-02248-5

#Corn's ancient ancestors are calling: #Genomic encyclopedia sheds light on #domestication 9,000 years ago.

#maize #teosinte #MaizeCODE #ENCODE #enhancers

https://phys.org/news/2025-02-corn-ancient-ancestors-genomic-encyclopedia.html

This allows condensate behaviour to respond to different inputs, such as lysine #acetylation in IDRs in other CBP domains. It can help to explain how #transcription factors binding to different regions of CBP differentially regulate CBP activity. #enhancers #generegulation #llps #chromatin #imaging #biochemistry #molecularbiology #CellBiology

#paperoftheday

Amazing work showing that #genetic #disruption of the #kinase module (CDK) of Mediator complex in chimeric #antigen receptor T cell (CAR T) resulted in enhanced effector function and increased #antitumor activity (disruption of CDK module increases core Mediator #chromatin occupancy at #enhancers)

https://www.science.org/doi/10.1126/science.abn5647

Hello. My name is Christopher Chase Bolt. Everyone calls me Chase. And this is my #ScienceMastadon introduction

I love #TranscriptionFactors and #Enhancers and their relationship to #GeneExpression. During my PhD at the #UniversityOfIllinois I studied the relationship between structural mutations in the genome and how they affect gene expression. #TissueCulture and #MouseGenetics n/n