#enhancers — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #enhancers, aggregated by home.social.
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The maternal-to-zygotic transition in #zebrafish is activated by TFs that open #chromatin via enhancers lacking H3K4me2. @MTLeeLab &co identify a parallel pathway that is activated by #enhancers that bear H3K4me2, showing that both act in combination @PLOSBiology https://plos.io/3IFqYMc
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The maternal-to-zygotic transition in #zebrafish is activated by TFs that open #chromatin via enhancers lacking H3K4me2. @MTLeeLab &co identify a parallel pathway that is activated by #enhancers that bear H3K4me2, showing that both act in combination @PLOSBiology https://plos.io/3IFqYMc
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#Corn's ancient ancestors are calling: #Genomic encyclopedia sheds light on #domestication 9,000 years ago.
#maize #teosinte #MaizeCODE #ENCODE #enhancers
https://phys.org/news/2025-02-corn-ancient-ancestors-genomic-encyclopedia.html
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#Corn's ancient ancestors are calling: #Genomic encyclopedia sheds light on #domestication 9,000 years ago.
#maize #teosinte #MaizeCODE #ENCODE #enhancers
https://phys.org/news/2025-02-corn-ancient-ancestors-genomic-encyclopedia.html
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*Very* exciting progress towards precision treatments for aggressive cancers. Very interesting science behind it too.
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*Very* exciting progress towards precision treatments for aggressive cancers. Very interesting science behind it too.
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This allows condensate behaviour to respond to different inputs, such as lysine #acetylation in IDRs in other CBP domains. It can help to explain how #transcription factors binding to different regions of CBP differentially regulate CBP activity. #enhancers #generegulation #llps #chromatin #imaging #biochemistry #molecularbiology #CellBiology
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How #cells in developing #embryos change the way they use #enhancers to regulate #gene #expression.
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Great to see this out- ABC was a great resource but this looks even better- was super interested to hear about it at #EMBOenhanceropathies a couple of weeks back #enhancers #generegulation https://www.biorxiv.org/content/10.1101/2023.11.09.563812v1
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PhD in Chromatin Biology
University College Dublin
#PhD position available at University College Dublin to work on the mechanisms of #enhancer dysregulation in acute myeloid #leukemia.
See the full job description on jobRxiv: https://jobrxiv.org/job/university-college-dublin-27778-phd-in-chromatin-biology/?feed_id=51768
#ScienceJobs #hiring #research #chromatin #transcription #enhancers #cance...
https://jobrxiv.org/job/university-college-dublin-27778-phd-in-chromatin-biology/?feed_id=51768 -
PhD in Chromatin Biology
University College Dublin
#PhD position available at University College Dublin to work on the mechanisms of #enhancer dysregulation in acute myeloid #leukemia.
See the full job description on jobRxiv: https://jobrxiv.org/job/university-college-dublin-27778-phd-in-chromatin-biology/?feed_id=51768
#ScienceJobs #hiring #research #chromatin #transcription #enhancers #cance...
https://jobrxiv.org/job/university-college-dublin-27778-phd-in-chromatin-biology/?feed_id=51768 -
Postdoc opportunity at JGI with
Li Lei and John Vogel:Using comparative genomics of polyploid grasses and plant engineering to identify and characterize cis-regulatory elements in plants.
https://jobs.lbl.gov/jobs/biological-sciences-postdoctoral-fellow-5890
#postdoc #plants #genomics #engineering #enhancers @LBNLBioSci
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Postdoc opportunity at JGI with
Li Lei and John Vogel:Using comparative genomics of polyploid grasses and plant engineering to identify and characterize cis-regulatory elements in plants.
https://jobs.lbl.gov/jobs/biological-sciences-postdoctoral-fellow-5890
#postdoc #plants #genomics #engineering #enhancers @LBNLBioSci
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Hallo all - I guess an introduction might be a good idea!
I'm a mid-career (already!?) group leader, trying to unpick how different aspects of the local environment at #enhancers work together to regulate #transcription and #geneexpression.
We especially like non-coding enhancer #RNA, how their structures and dynamic movements make them functional; how disease mutations affect #eRNA activity and how the enhancer environment affects the #chromatin regulator CBP.
Super-excited to land here!
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Hallo all - I guess an introduction might be a good idea!
I'm a mid-career (already!?) group leader, trying to unpick how different aspects of the local environment at #enhancers work together to regulate #transcription and #geneexpression.
We especially like non-coding enhancer #RNA, how their structures and dynamic movements make them functional; how disease mutations affect #eRNA activity and how the enhancer environment affects the #chromatin regulator CBP.
Super-excited to land here!
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The Brachyury (a.k.a. "T") gene is critical for development of the notochord - the defining feature of chordates (yes, that includes YOU!)
But what turns Brachyury on in the notochord?
Check out this new preprint:
https://www.biorxiv.org/content/10.1101/2023.04.20.536761v1@LBNLBioSci @berkeleylab #Brachyury #T #Enhancers #ShadowEnhancers
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The Brachyury (a.k.a. "T") gene is critical for development of the notochord - the defining feature of chordates (yes, that includes YOU!)
But what turns Brachyury on in the notochord?
Check out this new preprint:
https://www.biorxiv.org/content/10.1101/2023.04.20.536761v1@LBNLBioSci @berkeleylab #Brachyury #T #Enhancers #ShadowEnhancers
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Research paper alert! The @stark_lab shows in @genomeresearch that the activity of #enhancers is encoded through a combination of their motifs’ identity & context. 👇🏽 (1/2)
News article: https://www.imp.ac.at/news/article/decoding-the-grammar-of-gene-regulation
Paper: https://genome.cshlp.org/content/early/2023/03/20/gr.277246.122.abstract?sid=2281e6bc-b8cd-4c4f-8802-ef4bdae173b9 -
Research paper alert! The @stark_lab shows in @genomeresearch that the activity of #enhancers is encoded through a combination of their motifs’ identity & context. 👇🏽 (1/2)
News article: https://www.imp.ac.at/news/article/decoding-the-grammar-of-gene-regulation
Paper: https://genome.cshlp.org/content/early/2023/03/20/gr.277246.122.abstract?sid=2281e6bc-b8cd-4c4f-8802-ef4bdae173b9 -
#GeneRegulation digest #4:
🧬 New role of histone tails in nucleosome remodelling https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad079/7034407
🧬 TFBSs under accelerated #evolution in primates https://www.nature.com/articles/s41467-023-36421-3
🧬 Review of IDRs in #transcription regulators https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(23)00008-7
🧬 CpG islands & protection of genes from premature transcription termination https://www.nature.com/articles/s41467-023-36236-2
🧬 Regulation of #enhancers by DNA #methylation https://www.sciencedirect.com/science/article/pii/S1097276523000400
🧬 H2A-H2B & short-term memory of #chromatin states https://www.sciencedirect.com/science/article/pii/S0092867423000077
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#GeneRegulation digest #4:
🧬 New role of histone tails in nucleosome remodelling https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad079/7034407
🧬 TFBSs under accelerated #evolution in primates https://www.nature.com/articles/s41467-023-36421-3
🧬 Review of IDRs in #transcription regulators https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(23)00008-7
🧬 CpG islands & protection of genes from premature transcription termination https://www.nature.com/articles/s41467-023-36236-2
🧬 Regulation of #enhancers by DNA #methylation https://www.sciencedirect.com/science/article/pii/S1097276523000400
🧬 H2A-H2B & short-term memory of #chromatin states https://www.sciencedirect.com/science/article/pii/S0092867423000077
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Happy to announce that our story on #DNAmethylation at #enhancers is out in
Molecular Cell! 👣🧬
https://doi.org/10.1016/j.molcel.2023.01.017
It was a fantastic PhD journey in the lab of @arnaud_kr @embl➡️ Our study highlights the intricate relationship between DNA methylation and enhancer regulation and reveals that most enhancers are not instructed by 5mC. Yet, methyl-sensitive enhancers are highly dependent on TET activity.
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Amazing work showing that #genetic #disruption of the #kinase module (CDK) of Mediator complex in chimeric #antigen receptor T cell (CAR T) resulted in enhanced effector function and increased #antitumor activity (disruption of CDK module increases core Mediator #chromatin occupancy at #enhancers)
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Amazing work showing that #genetic #disruption of the #kinase module (CDK) of Mediator complex in chimeric #antigen receptor T cell (CAR T) resulted in enhanced effector function and increased #antitumor activity (disruption of CDK module increases core Mediator #chromatin occupancy at #enhancers)
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Hello. My name is Christopher Chase Bolt. Everyone calls me Chase. And this is my #ScienceMastadon introduction
I love #TranscriptionFactors and #Enhancers and their relationship to #GeneExpression. During my PhD at the #UniversityOfIllinois I studied the relationship between structural mutations in the genome and how they affect gene expression. #TissueCulture and #MouseGenetics n/n
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Hello #ScienceMastodon Twitter refugees
#introduction I am a 🇫🇷 molecular & structural biologist working at the CNRS. I study the molecular mechanisms that control human gene expression focusing on #transcription factors & the Pol II machinery
Expect to see here a lot of info on #generegulation, #enhancers, #histone modifications & structural insights into the eukaryotic Transcription Initiation machinery. #CryoEM
I will also highlight #womeninscience to give them the visibility they deserve -
Hello #ScienceMastodon Twitter refugees
#introduction I am a 🇫🇷 molecular & structural biologist working at the CNRS. I study the molecular mechanisms that control human gene expression focusing on #transcription factors & the Pol II machinery
Expect to see here a lot of info on #generegulation, #enhancers, #histone modifications & structural insights into the eukaryotic Transcription Initiation machinery. #CryoEM
I will also highlight #womeninscience to give them the visibility they deserve