#e627k — Public Fediverse posts

A rapid #review of the avian #influenza #PB2 #E627K #mutation in #human infection studies, https://etidiohnew.blogspot.com/2025/04/a-rapid-review-of-avian-influenza.html

''Compared to the Svalbard avian index case, #PB2 #segment of the walrus sequence contained only 2 aa #substitutions, including #E627K mutation, which is known to enhance #infectivity in #mammals. Interestingly, all avian HPAIV H5N5 from Norway, as well as the walrus sequence, have a set of 6 aa in PB2 that have been reported to favour infection of mammals [Citation11].''

Characterization of #H5N1 avian #influenza virus isolated from #bird in #Russia with the #E627K mutation in the #PB2 protein

Source: Scientific Reports, AbstractCurrently A(H5Nx) avian influenza viruses are globally widespread and continue to evolve. Since their emergence in 2020 novel highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b reassortant viruses have become predominant in the world and caused multiple infections in mammals. It was shown that some of…

https://etidioh.wordpress.com/2024/11/04/characterization-of-h5n1-avian-influenza-virus-isolated-from-bird-in-russia-with-the-e627k-mutation-in-the-pb2-protein/

#Outcome of #H5N1 clade 2.3.4.4b virus #infection in #calves and lactating #cows, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.08.09.607272v1

Adaptive #mutation #PB2 #E627K emerged after intramammary #replication of H5N1 euDG. Our data suggest that in addition to H5N1 B3.13, other HPAIV H5N1 strains have potential to replicate in #udder of cows & that #milk & milking procedures, rather than respiratory spread, are likely the primary routes of H5N1 #transmission between cattle.