Interesting talk by Elena Reckzeh at #ICBS2026.
She gave a broad overview of the many different applications of organoids in Drug Discovery that her group is developing.
#Organoids #DrugDiscovery #ChemBio #Chemistry #DrugDevelopment
#drug-discovery — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #drug-discovery, aggregated by home.social.
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Amazing talk by Brian Paegel at #ICBS2026.
He talked about his group's exciting work on using DNA-encoded libraries for phenotypic screening for effectors of human signaling and for #antibiotics.
https://pubs.acs.org/acscii/article/9/8/1603/1282515/Hydrogel-Encapsulated-Beads-Enable-Proximity
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How can the targeted degradation of #RNA be exploited to treat diseases?
Peng Wu gave an insightfull talk at #ICBS2026 on his group's work on RNA-degrading RIBOTACs e.g. on the example of an NRAS mRNA degrader with implications in #cancer.
#Degradation #Degrader #mRNA #DrugDiscovery #ChemBio #Chemistry #Science
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How can we specifically address RNA with small molecules?
Amanda Garner gave an exciting talk at #ICBS2026, in which she discussed her group's work on developing tools for studying small molecule-RNA interactions in cells and disrupting RNA-protein interactions.
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https://www.europesays.com/dk/184948/ GLP-1 Drugs Push Food Industry to Rethink Portions, Products #Anthropic #ArtificialIntelligence #AWS #COFEPRIS #ConAgraBrands #ConsumerBehavior #DrugDiscovery #ENSANUT #FoodIndustry #GLP1 #INSP #Nestlé #NovoNordisk #Nutrition #Obesity #openai #semaglutide #WHO
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https://www.europesays.com/dk/184926/ Eli Lilly won the first round of the weight-loss boom. Who wins next? #Absci #ArtificialIntelligence #ConsumerStaples #DrugDiscovery #EliLilly #GLP1 #Hims&Hers #NovoNordisk #VikingTherapeutics #WeightLossDrugs
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Is arginine a viable target for #CovalentInhibitor development?
Lately, this topic has seen a lot of movement with the development of new chemoproteomics technologies and warheads. The groups of Balyn Zaro and Ian Seiple now add ninhydrin as a promising warhead to the toolbox to address this question.
https://doi.org/10.1021/acscentsci.6c00922
#DrugDiscovery #Chemistry #ChemBio #Chemoproteomics #Science
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DATE: October 12, 2026 at 08:43PM
SOURCE: SCIENCE DAILY MIND-BRAIN FEEDTITLE: After 30 years, scientists finally have a drug for a deadly brain disease
URL: https://www.sciencedaily.com/releases/2026/10/261007042111.htm
The FDA has approved the first drug that directly targets Alexander disease, a devastating neurological disorder affecting fewer than one in a million people. Developed through decades of research, Zanvastro showed promising results in clinical trials, stabilizing motor function and even improving movement in some patients.
URL: https://www.sciencedaily.com/releases/2026/10/261007042111.htm
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#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #AlexanderDisease #Neurology #FDAApproval #RareDisease #Neurodegenerative #DrugDiscovery #MedicalResearch #ClinicalTrials #BrainHealth #Zanvastro
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Speeding up hope for rare neuromuscular diseases | News | CORDIS
The EU-backed DREAMS project is hosting a webinar to explore current AI applications for tackling different challenges in…
#Europe #EU #EuropeanCommission #disease #disorder #DREAMS #DrugDiscovery #healthcare #neuromusculardisease #NMD #rareneuromusculardisease
https://www.europesays.com/europe/157923/ -
Interesting talk by Ross Sibley from the group of Alison Axtman at #ICBS2026.
He talked about his work on casein kinase 2 (CK2)-directed PROTACs for targeting #Alzheimers.
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What to do, if cancer cells become resistant to a #CovalentInhibitor by mutating the reactive cysteine?
At #ICBS2026, Celine Wang from the group of Ziyang Zhang talked about her research into addressing BTK C481S with a β-lactone that targets the catalytic lysine.
https://www.biorxiv.org/content/10.64898/2026.07.03.736436v1
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Interesting talk by Julius Pampel from the group of Kevan Shokat at #ICBS2026.
He talked about his work on targeting K-Ras Q61 mutants with #CovalentInhibitors.
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Interesting talk by Andrea Arrieche Suarez at #ICBS2026.
She talked about her work on selective #autophagy inhibitors by targeting ATG14L-Beclin interaction to treat ovarian #cancer.
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Interesting talk by Jinsu Bae from the group of Michelle Arkin at #ICBS2026.
He talked about the potential of oncogenic Gαq as a tatget in treating uveal melanoma and their work towards addressing it with a #CovalentInhibitor.
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I had a great time and hope to be back for the next event in 2028.
#CovalentInhibitor #DrugDiscovery #ChemicalProteomics #ChemBio #Chemistry #Science
(7/7)
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A true firework of covalent drug discovery to close out the Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov!
Ed Tate presented a variety of exciting projects of his group.
#CovalentInhibitor #DrugDiscovery #Chemistry #ChemBio #Science
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Interesting talk by Michael Bodnarchuk from Astra Zeneca at #CovModDrugDiscov.
He talked about the use of computational tools to discover covalent, brain-penetrant KRAS G12C inhibitors.
#CovalentInhibitor #DrugDiscovery #Chemistry #ChemBio #Science
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Exciting talk by Yoav Shamir from the group of Nir London at #CovModDrugDisvov!
He talked about cofolding in Alphafold3 to identify #CovalentInhibitors with novel structures on the example of BTK.
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AI Takes Aim at Biology With $1.8 Billion Virtual Cell Initiative
A $1.8 billion initiative is using AI and massive biological datasets to build a virtual cell that could transform disease research and drug discoveryhttps://alhlwone.wordpress.com/2026/10/08/ai-virtual-cell-biology-drug-discovery/
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Interesting talk by Chloe Oxford from GSK at #CovModDrugDiscov.
She talked about a MALDI-TOF-MS-based assay to characterize the binding of #CovalentInhibitors to challenging proteins with resolution of the binding site.
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Interesting talk by Federica Raguseo at #CovModDrugDiscov.
She talked about a phenotype-first approach to covalent drug discovery on the example of TYMS.
https://www.biorxiv.org/content/10.64898/2026.06.10.731339v1.abstract
#CovalentInhibitor #DrugDiscovery #Chemistry #ChemBio #Science
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Exciting talk by Megan Wright at #CovModDrugDiscov.
She talked about new chemical methods to make libraries of covalent compounds and using them in MS-based and phenotypic screens.
https://pubs.rsc.org/cb/article/7/5/862/1228755/High-throughput-discovery-and-characterisation-of
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Interesting talk by Darrin McKenzie at #CovModDrugDiscov.
He talked about, how they set up an automated platform to study protein expression levels and cysteine engagement in living cells.
#CovalentInhibitor #DrugDiscovery #ChemBio #Chemistry #ChemicalProteomics #Science
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Always great to see the amazing work by Patrick Zanon in our group highlighted in the talk of others. (2/2) https://www.nature.com/articles/s41557-025-01902-z
#CovalentInhibitor #DrugDiscovery #Chemistry #ChemBio #Science #ChemPro #ProteoProbes
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The 2nd day of #CovModDrugDiscov gets on the way with an inspiring talk by Steven Gygi.
He talked about the power of TMT technologies for multiplexing to arrive at high-throughput residue-specific chemoproteomics.
#CovalentInhibitor #DrugDiscovery #Chemistry #ChemBio #ChemicalProteomics #Science
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Inspiring talk by Scott Lovell at #CovModDrugDiscov.
He talked about the development of macrocyclic #peptides into covalent inhibitors targeting lysines using SuFEx chemistry.
https://www.biorxiv.org/content/10.64898/2026.05.20.726481v1
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Interesting talk by Louise Walport at #CovModDrugDiscov.
She talked about the discovery of potent peptide-based #CovalentInhibitors using mRNA display.
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Interesting talk by Madeeha Ali at #CovModDrugDiscov.
She talked about her exciting work on studying the kinetics of #CovalentInhibitors.
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70373
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Great talk by David Heppner at #CovModDrugDiscov.
He gave exciting insights into rigorously characterizing #CovalentInhibitors using crystal structures and kinetics.
https://pubs.acs.org/abmcb8/article/6/4/293/5159058/Epidermal-Growth-Factor-Receptor-as-a-Model-Drug
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Insightful talk by Matthias Gehringer at #CovModDrugDiscov.
He gave great insights into his group's work on making new kinases amenable to covalent drug discovery at cysteine and beyond.
https://onlinelibrary.wiley.com/doi/10.1002/anie.202419736
#CovalentInhibitor #DrugDiscovery #Chemistry #ChemBio #Science #Kinase
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We had an amazing poster session at #CovModDrugDiscov! I learned a lot about new warheads, covalent binder optimization and methods to measure target engagement.
Thank you to all presenters for sharing their amazing science.
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Interesting talk by Jonathan Pettinger from GSK at #CovModDrugDiscov.
He talked about the power of direct-to-biology (D2B) approaches for fast SAR studies of #CovalentInhibitors.
https://chemrxiv.org/doi/10.26434/chemrxiv-2025-tvdzn
#D2B #DirectToBiology #DrugDiscovery #ChemBio #Chemistry #Science
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The Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov continues with an interesting talk by Mandy Ferdinand from Cancer Research Horizons.
She talked about methods to characterize covalent hits with a special focus on binding kinetics.
#CovalentInhibitor #DrugDiscovery #Chemistry #ChemBio #Science
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The Covalent Modulation in Drug Discovery Conference #CovModDrugDiscov is off to a great start with an insightful talk by Matt Bilyard from Roche.
He talked about how they select targets for covalent drug discovery and then find and develop covalent binders.
#CovalentInhibitor #DrugDiscovery #ChemBio #Chemistry #Science