#donepezil — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #donepezil, aggregated by home.social.
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The reason I'm wondering about hydrogen sulfide is because it induces torpor.
I did some searching and found a study suggesting similarities between H2S and donepezil -"Exogenous H2S up-regulates the expression of ADAM10 and ADAM17 and sAPPα, and effectively reduce the production of Aβ40, Aβ42 and sAPPβ in vitro in PC12. The PI3-K or JNK signal pathway may be involved in the regulation. Donepezil has similar effects as H2S, which involves PI3-K, JNK or p38 MAPK signaling."
https://doi.org/10.1016/j.niox.2012.08.012So now I'm wondering why donepezil isn't disease modifying in Alzheimer's. However, I found this -
Donepezil delays progression to AD in MCI subjects with depressive symptoms
https://doi.org/10.1212%2FWNL.0b013e3181aa52d3 -
Neues Medikament gegen Magersucht? Wirkstoff Donepezil lindert Anorexia nervosa bei Maus und Mensch. #Magersucht #Anorexie #Donepezil #Anorexianervosa
https://www.scinexx.de/news/medizin/neues-medikament-gegen-magersucht/