#cidofovir — Public Fediverse posts

#Treatment #efficacy of #cidofovir & #brincidofovir vs clade II #mpox virus isolates, Antiviral Res.: https://www.sciencedirect.com/science/article/pii/S0166354224002043?via%3Dihub

Cidofovir & brincidofovir display broad-spectrum #antiviral activity vs MPXV clades I, IIa, and IIb in vitro. Systemic administration of active compound cidofovir prevents MPXV replication in mouse #respiratory tract. Oral treatment with brincidofovir limits viral replication in vivo vs a non-lethal MPXV clade IIb challenge.

NPP-669 is a promising #Cidofovir #prodrug acting as #broad #spectrum #antiviral agent (#BSAA) against multiple DNA #viruses.
An excellent example on how #chemistry / #medicinalchemistry play a key role in the improvement of #drug #bioavalilability and clinical efficacy of #drug candidates.

https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.2c00668#

NPP-669 is a promising #Cidofovir #prodrug acting as #broad #spectrum #antiviral agent (#BSAA) against multiple DNA #viruses.
An excellent example on how #chemistry / #medicinalchemistry play a key role in the improvement of #drug #bioavalilability and clinical efficacy of #drug candidates.

https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.2c00668#

NPP-669 is a promising #Cidofovir #prodrug acting as #broad #spectrum #antiviral agent (#BSAA) against multiple DNA #viruses.
An excellent example on how #chemistry / #medicinalchemistry play a key role in the improvement of #drug #bioavalilability and clinical efficacy of #drug candidates.

https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.2c00668#

NPP-669 is a promising #Cidofovir #prodrug acting as #broad #spectrum #antiviral agent (#BSAA) against multiple DNA #viruses.
An excellent example on how #chemistry / #medicinalchemistry play a key role in the improvement of #drug #bioavalilability and clinical efficacy of #drug candidates.

https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.2c00668#