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#checkpointinhibitor — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #checkpointinhibitor, aggregated by home.social.

  1. Improving Ovarian Cancer Immunotherapy: Cancer immunologists at the University of Virginia have now discovered what underlies this failure. #immunotherapy #checkpointinhibitor #ovarian #cancer #biome #flagellin
    instagram.com/reel/DHDygk-shuL

  2. The effects of the CTLA4 deletion were not very surprising, what's fascinating here is how it compares to the double mutants (PD1/CTLA4).

    "CTLA4 disrupted CART19 cells display prolonged surface CAR expression, increased proliferation, and enhanced CART19 effector function supported by unopposed CD28 co-stimulation, which is lost in CART19 cells deficient for both PD-1 and CTLA4"

    #Immunology #Immunotherapy #CheckpointInhibitor #CTLA4 #CARTcells

    cell.com/immunity/fulltext/S10

  3. What if we could trace #cytotoxic #Tcells throughout the human body before and during #cancer #immunotherapy?

    Researchers at the University of Groningen have used a CD8-specific positron emission tomography (#PET) tracer in a phase 1/2 clinical trial. Patients with solid tumors were imaged before and ~30 days after starting treatment with #antibodies against PD-L1, PD-1, and/or CTLA-4.

    Article in Nature Medicine: nature.com/articles/s41591-022

    #checkpointinhibitor #solidtumor #clinicaltrial