#checkpointinhibitor — Public Fediverse posts

Improving Ovarian Cancer Immunotherapy: Cancer immunologists at the University of Virginia have now discovered what underlies this failure. #immunotherapy #checkpointinhibitor #ovarian #cancer #biome #flagellin
https://www.instagram.com/reel/DHDygk-shuL/

This one is for adults with primary advanced or recurrent endometrial cancer.

"This new approval is based on data from the Phase 3 NRG-GY018 trial, also known as KEYNOTE-868. Results reported last year in the New England Journal of Medicineshowed a 70% lower risk of disease progression when patients were treated with pembrolizumab and chemotherapy."
#Immunology #Immunotherapy #CheckpointInhibitor
https://www.cancerresearch.org/blog/june-2024/keytruda-receives-40th-fda-approval?utm_source=Social&utm_medium=LinkedIn&utm_campaign=CRI&utm_id=CRI

"Novartis’ anti-TIM-3 antibody has flunked a phase 3 blood cancer trial, prompting the Swiss drugmaker to pull the drug candidate from its pipeline. The failed study was the biggest test to date of an immuno-oncology target into which a who’s who of leading drug developers have pumped money."
#Immunology #immunotherapy #CheckpointInhibitor

https://www.fiercebiotech.com/biotech/novartis-calls-time-tim-3-axing-cancer-candidate-after-phase-3-flop

AlphaFold & PDL1

"Here, we test a protein design pipeline that uses iterative rounds of deep learning (DL)-based structure prediction (AlphaFold2) and sequence optimization (ProteinMPNN) to design autoinhibitory domains (AiDs) for a PD-L1 antagonist."
#Immunology #CheckpointInhibitor

https://www.pnas.org/doi/10.1073/pnas.2307371120

The effects of the CTLA4 deletion were not very surprising, what's fascinating here is how it compares to the double mutants (PD1/CTLA4).

"CTLA4 disrupted CART19 cells display prolonged surface CAR expression, increased proliferation, and enhanced CART19 effector function supported by unopposed CD28 co-stimulation, which is lost in CART19 cells deficient for both PD-1 and CTLA4"

#Immunology #Immunotherapy #CheckpointInhibitor #CTLA4 #CARTcells

https://www.cell.com/immunity/fulltext/S1074-7613(23)00407-7#secsectitle0075

A clinical trial assessing a synthetic antibody to generate an immediate response and also generate a more durable treatment for solid tumor cancers, advanced to a mid-stage study.

https://sciencebusiness.technewslit.com/?p=45068

#News #Press #Science #Business #Cancer #Biotechnology #ClinicalTrial #Immunotherapy #AdverseEffects #CheckpointInhibitor #Antibody #ImmuneSystem #TCells #InnateImmuneSystem

Very interesting case report of pulse methylprednisolone in treatment of steroid-refractory #Immune #CheckPointInhibitor #pneumonitis

We also treated a patient with a grade IV pneumonitis with high dose steroid. My observation is a very rapid improvement, within 48h.

Further research is needed but it could be promising for life-threatening immune checkpoint inhibitor reaction

https://pubmed.ncbi.nlm.nih.gov/36119082/

#MedMastodon #FOAMcc #FOAMed

What if we could trace #cytotoxic #Tcells throughout the human body before and during #cancer #immunotherapy?

Researchers at the University of Groningen have used a CD8-specific positron emission tomography (#PET) tracer in a phase 1/2 clinical trial. Patients with solid tumors were imaged before and ~30 days after starting treatment with #antibodies against PD-L1, PD-1, and/or CTLA-4.

Article in Nature Medicine: https://www.nature.com/articles/s41591-022-02084-8

#checkpointinhibitor #solidtumor #clinicaltrial