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#cellfate — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #cellfate, aggregated by home.social.

  1. Stephen Matheson🌵🌲 @[email protected] ·

    Second half of the "variation and information" session #CSSingleCells23
    led off by Sam Morris of WashU
    morrislab.wustl.edu/

    Multi-omic lineage tracing: insights into reprogramming cell identity

    her piece in *Development*, "The evolving concept of cell identity in the single cell era"

    working on "induced hepatocytes", start with fibroblasts, via "induced endoderm progenitors"

    new work on #adipocytes
    biorxiv.org/content/10.1101/20

    #reprogramming
    #StemCells
    #CellIdentity
    #CellFate

    1/2

    #cellfate #cellidentity #stemcells #reprogramming #adipocytes #cssinglecells23
  2. Julien Delpierre @[email protected] ·
    CW: Combinatorial interpretation of BMP and WNT allows BMP to act as a morphogen in time but not in concentration.

    "[...] varying the duration of #BMP #signaling leads to either pluripotent, mesodermal, and extraembryonic states, while varying the concentration does not cause efficient mesodermal differentiation at any dose [...] appropriately timed pulse of BMP induces #hPSCs to a mesodermal fate more efficiently that sustained signaling at any concentration. [...] this effect is due to a combinatorial interpretation of the applied BMP signal and induced endogenous #Wnt signaling."
    biorxiv.org/content/10.1101/20
    #DevBio #CellFate #GermLayers #morphogens #Differentiation

    #differentiation #hpscs #bmp #signaling #wnt #devbio