#celladhesion — Public Fediverse posts

Now published... and on the #BiophysJ cover!

Cell Adhesion Pattern Shows Conserved #Scalings under #Geometrical Control

Studying the relationship between the size and the #anatomy and #physiology of #living #organisms has proven useful in deciphering what the key physical constraints are that apply to them. For instance, total adhesive pad area is found to #scale like organism mass over a wide variety of animal species, possibly to resist against body weight.

In this study, we apply this approach at the cell scale to ask how large-scale geometrical constraints affect the organisation of #adhesion patches and the size of #cellSubstrate contact at different stages of the #cellSpreading process. Indeed, #cells, like many animals, adhere to their substrate. For that, they use specific protein complexes, called #focalAdhesions, which form patches often situated at the cell periphery.

cc @JonFouchard

https://www.biophysics.org/blog/cell-adhesion-pattern-shows-conserved-scalings-under-geometrical-control

#cellAdhesion #biophysics #allometry

#introduction:
We are a new cell systems biology team at the #UniversityOfManchester #UoM.
We study #CellAdhesion #networks in health and disease, especially #cancer.
Fascinated by how adhesion proteins help #cells function in so many ways!

#proteomics #integrins #adhesion #cytoskeleton #nucleus #bioinformatics #omics #ExtracellularMatrix #ECM #NetworkBiology #DataViz

#introduction:
I am a Lecturer and #NewPI at the #UniversityOfManchester #UoM
I am interested in how cellular interactions with the tumour microenvironment control fundamental aspects of cancer cell behaviour, including regulation of gene expression.
In @thebyronlab, we combine #proteomics, #sequencing, #bioinformatics, functional #CellBiology, super-resolution #imaging and #cancer models, to discover new properties of cancer #CellAdhesion #networks.