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  1. There's a new Parkinson disease research article out that I just started reading, but I'm dismayed by the very first sentence in the abstract.

    "Exposure to carbon disulfide (CS2) is a recognized risk factor in the pathogenesis of Parkinson’s disease, yet the underlying mechanisms of deleterious effects on mitochondrial integrity have remained elusive. "

    Although exposure to CS2 causes parkinsonism, CS2 exposure isn't a recognized risk factor for PD. However,
    a case could be made
    for a link between chronic CS2 exposure and multiple system atrophy.

    The article is:

    Liu et al. (2024)
    Mitochondrial transfer of α-synuclein mediates carbon disulfide-induced mitochondrial dysfunction and neurotoxicity
    doi.org/10.1016/j.ecoenv.2024.

    Here's a link to my hypothesis paper on CS2 and aging which reviews the harms of CS2 and provides supporting references:
    docs.google.com/document/d/155

    I will probably post more on Liu et al. 2024 after I get a chance to really study it.

    #Parkinsons #CarbonDisulfide
    #neuroscience

  2. CW: Carbon disulfide & aging

    Last year the Longevity Prize offered a $20k Hypothesis Prize. I submitted something since I figured its probably better odds than the lottery. The submission was due at end of last year, but so far no updates to the page & no announcement of a winner. Whatever.🤷

    I was left completely drained by the effort - but I learned a lot of fascinating things.

    Here's my submission:
    docs.google.com/document/d/155

    #Aging #health #neuroscience #GutMicrobiome #CS2 #sulfation #CarbonDisulfide

  3. CW: death

    “She was given Antabuse to treat her alcoholism, but an autopsy upon her death (which was due to falling from a window, not cancer) revealed that her body was clinically cancer-free despite having no further cancer treatment.”

    She fell from a window. 🤔

    newsweek.com/cancer-treatment-

    #disulfiram #CarbonDisulfide #DrugRepurposing #SideEffects

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