#carbapenem — Public Fediverse posts

Within-Patient Carbapenem Heteroresistance in #Klebsiella pneumoniae Associated with a Repeat-Associated blaNDM-1 Resistance-Module Deletion.

#carbapenem resistance can shift via repeat‑driven plasmid deletions yielding divergent phenotypes.

#OpenAccess #Microbiology #antibiotics

https://davidojcius.blogspot.com/2026/08/repeatdriven-plasmid-deletions-cause.html

Outbreak: #Carbapenem Producing Organism

Facility: LHSC - University Hospital
Facility Type: Hospital (Acute Care)
Unit/Floor/Area: U4-Med
Location: #London #Ontario
Facility Tracking Hash: #MLHU0001

Date: 2026-08-13

Public Health Unit: Middlesex-London Health Unit
PHU Tracking Hash: #OnObMLHU

Click or follow tracking hashtags to see data for individual facilities or a specific public health unit.

#CPO

Outbreak: #Carbapenem Producing Organism

Facility: LHSC - University Hospital
Facility Type: Hospital (Acute Care)
Unit/Floor/Area: U4-Multi-Organ Transplant Unit
Location: #London #Ontario
Facility Tracking Hash: #MLHU0001

Date: 2026-08-04

Public Health Unit: Middlesex-London Health Unit
PHU Tracking Hash: #OnObMLHU

Click or follow tracking hashtags to see data for individual facilities or a specific public health unit.

#CPO

#Meropenem Stress Drives Lipid Remodeling and Resistance Gene Dissemination via Outer Membrane Vesicles in #Carbapenem -Resistant #Klebsiella pneumoniae

#OpenAccess #AntibioticResistance #Microbiology

https://davidojcius.blogspot.com/2026/05/meropenem-stress-drives-lipid.html

Nutrient-Driven Small-Colony Variants as an Adaptive Outcome in #Carbapenem -Resistant #Acinetobacter baumannii

#OpenAccess #AntibioticResistance #microbiology

https://davidojcius.blogspot.com/2026/05/nutrient-driven-small-colony-variants.html

MrkA enhances the virulence phenotype of #carbapenem -resistant #Klebsiella pneumoniae both in vitro & in vivo.

MrkA drives CRKP virulence by linking iron uptake, adhesion & carbon metabolism, with deletion sharply reducing pathogenicity.

#OpenAccess #antibioticresistance #microbiology

https://davidojcius.blogspot.com/2026/03/mrka-enhances-virulence-phenotype-of.html

Therapeutic challenges & Emerging Strategies against #Carbapenem -Resistant #Acinetobacter baumannii.

Emerging agents like sulbactam‑durlobactam, eravacycline & cefiderocol offer new options against multifaceted CRAB resistance.

https://davidojcius.blogspot.com/2026/03/therapeutic-challenges-and-emerging.html

#OpenAccess #microbiology #antibioticresistance

Outbreak: #Carbapenem Producing Organism ( #CPO )

Facility: LHSC - University Hospital
Facility Type: Hospital (Acute Care)
Unit/Floor/Area: U4 Multiorgan Transplant Unit
Location: #London #Ontario
Facility Tracking Hash: #MLHU0001

Date: 2026-03-10

Public Health Unit: Middlesex-London Health Unit
PHU Tracking Hash: #OnObMLHU

Click or follow tracking hashtags to see data for individual facilities or a specific public health unit.

Tn4401/Tn7247 transposon-derived structures driving the cross-transmission of blaKPC among plasmids and chromosomes in clinical #carbapenem-resistant #Pseudomonas aeruginosa

https://www.sciencedirect.com/science/article/pii/S2666517426000180 #OpenAccess #AntibioticResistance #Microbiology

Outbreak: #Carbapenem Producing Organism (#CPO)
Facility: Victoria Hospital
Facility Type: Hospital (Acute Care)
Unit/Floor/Area: C7-400 Oncology
Location: #London #Ontario
Date: 2026-01-08

Public Health Unit: Middlesex-London Health Unit
Facility Tracking Hash: #MLHU0016
PHU Tracking Hash: #OnObMLHU

Click or follow tracking hashtags to see data for individual facilities or a specific public health unit.

Outbreak: #Carbapenem Producing Organism (#CPO)
Facility: Victoria Hospital
Facility Type: Hospital (Acute Care)
Unit/Floor/Area: C7-200 Inpatient Oncology
Date: 2025-05-20

Public Health Unit: Middlesex-London Health Unit
Facility Tracking Hash: #MLHU0016
PHU Tracking Hash: #OnObMLHU

Click or follow tracking hashtags to see data for individual facilities or a specific public health unit.

https://picnet.ca/surveillance/cpo/

#Antimicrobial #Resistance, Hypervirulent #Klebsiella pneumoniae - #Global #situation, #WHO D.O.N.: https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON527

...to assess current global situation given increased identification of isolates of #Klebsiella p. (hvKp) sequence type #ST23 carrying resistant #genes to #carbapenem #antibiotics reported in several countries. Documented sustained #transmission of this lineage has been observed over several years & genes associated with AMR were detected in ...in multiple countries.

Experimental antibiotic kills deadly superbug, opens whole new class of drugs - Enlarge / This Scanning Electron Microscope image depicts several clust... - https://arstechnica.com/?p=1994119 #carbapenem-resistantacinetobacterbaumannii #acinetobacterbaumannii #gram-negativebacteria #antibioticresistance #drugdevelopment #antibiotic #bacteria #science #health #roche #crab #lps

This is interesting - providing individualised antibiotic plans safely reduces #carbapenem prescriptions.

But isn't this just what happens in specialties, like #hematology or #intensivecare, that get regular #microbiology / #infectiousdisease #MDT review of their #antibiotic prescriptions?
#IDmastodon #medicine #oncology #orthopedics #ICU #AMR #pediatrics #criticalcare
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciad518/7255898?redirectedFrom=fulltext&utm_source=advanceaccess&utm_campaign=cid&utm_medium=email

We may be losing #cefiderocol far sooner than we hoped.

Timely meta-analysis. Look at those #resistance rates in #carbapenem resistant Enterobacterales!

#microbiology #AMR #antibiotics #antibiotic #CriticalCare #Pseudomonas #Acenitobacter #infectiousdiseases #IDMastodon #medicine

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(23)00413-5/fulltext?dgcid=raven_jbs_aip_email

'' It is possible for continuous #recombination to occur within #carbapenem-resistant #Enterobacteriaceae (#CRE) during infection. In contrast to exogenously-acquired resistance, greater attention should be placed on the endogenous factors that contribute to the development of CRE within healthcare settings.''

Early initiation of three-drug #combinations for the #treatment of #carbapenem-resistant #Acinetobacter baumannii among #COVID19 patients https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkad042/7069111?rss=1

Restrict #carbapenem use and... people will use less carbapenem!

#AMR #microbiology #IDMastodon #MedMastodon @MicrobioJC

Can’t keep it SECRET: system evaluation of carbapenem restriction against empirical therapy | JAC-Antimicrobal Resistance

https://academic.oup.com/jacamr/article/5/1/dlac137/6966934