home.social

#biophysical — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #biophysical, aggregated by home.social.

  1. 🧠 New paper by Deistler et al: #JAXLEY: differentiable #simulation for large-scale training of detailed #biophysical #models of #NeuralDynamics.

    They present a #differentiable #GPU accelerated #simulator that trains #morphologically detailed biophysical #neuron models with #GradientDescent. JAXLEY fits intracellular #voltage and #calcium data, scales to 1000s of compartments, trains biophys. #RNNs on #WorkingMemory tasks & even solves #MNIST.

    🌍 doi.org/10.1038/s41592-025-028

    #Neuroscience #CompNeuro

  2. 🧠 New paper by Deistler et al: #JAXLEY: differentiable #simulation for large-scale training of detailed #biophysical #models of #NeuralDynamics.

    They present a #differentiable #GPU accelerated #simulator that trains #morphologically detailed biophysical #neuron models with #GradientDescent. JAXLEY fits intracellular #voltage and #calcium data, scales to 1000s of compartments, trains biophys. #RNNs on #WorkingMemory tasks & even solves #MNIST.

    🌍 doi.org/10.1038/s41592-025-028

    #Neuroscience #CompNeuro

  3. 🧠 New paper by Deistler et al: #JAXLEY: differentiable #simulation for large-scale training of detailed #biophysical #models of #NeuralDynamics.

    They present a #differentiable #GPU accelerated #simulator that trains #morphologically detailed biophysical #neuron models with #GradientDescent. JAXLEY fits intracellular #voltage and #calcium data, scales to 1000s of compartments, trains biophys. #RNNs on #WorkingMemory tasks & even solves #MNIST.

    🌍 doi.org/10.1038/s41592-025-028

    #Neuroscience #CompNeuro

  4. 🧠 New paper by Deistler et al: #JAXLEY: differentiable #simulation for large-scale training of detailed #biophysical #models of #NeuralDynamics.

    They present a #differentiable #GPU accelerated #simulator that trains #morphologically detailed biophysical #neuron models with #GradientDescent. JAXLEY fits intracellular #voltage and #calcium data, scales to 1000s of compartments, trains biophys. #RNNs on #WorkingMemory tasks & even solves #MNIST.

    🌍 doi.org/10.1038/s41592-025-028

    #Neuroscience #CompNeuro

  5. 🧠 New preprint by Chintaluri et al. (2025): An ion channel #omnimodel for standardized #biophysical #neuron #modelling. A unified #HodgkinHuxley formalism applied to >3,500 ion channel models from #ModelDB. Enables cross-model comparison, #clustering, and reproducible simulation through a shared parametrization:

    🌍 doi.org/10.1101/2025.10.03.680

    #CompNeuro #Neuroscience #Reproducibility

  6. 🧠 New preprint by Chintaluri et al. (2025): An ion channel #omnimodel for standardized #biophysical #neuron #modelling. A unified #HodgkinHuxley formalism applied to >3,500 ion channel models from #ModelDB. Enables cross-model comparison, #clustering, and reproducible simulation through a shared parametrization:

    🌍 doi.org/10.1101/2025.10.03.680

    #CompNeuro #Neuroscience #Reproducibility

  7. 🧠 New preprint by Chintaluri et al. (2025): An ion channel #omnimodel for standardized #biophysical #neuron #modelling. A unified #HodgkinHuxley formalism applied to >3,500 ion channel models from #ModelDB. Enables cross-model comparison, #clustering, and reproducible simulation through a shared parametrization:

    🌍 doi.org/10.1101/2025.10.03.680

    #CompNeuro #Neuroscience #Reproducibility

  8. 🧠 New preprint by Chintaluri et al. (2025): An ion channel #omnimodel for standardized #biophysical #neuron #modelling. A unified #HodgkinHuxley formalism applied to >3,500 ion channel models from #ModelDB. Enables cross-model comparison, #clustering, and reproducible simulation through a shared parametrization:

    🌍 doi.org/10.1101/2025.10.03.680

    #CompNeuro #Neuroscience #Reproducibility

  9. Recently, we discussed this insightful paper by Squadrani et al (2024) in our #JournalClub. It explores how #astrocytes enhance #SynapticPlasticity during #ReversalLearning by modulating D-serine levels, providing a #biophysical basis for dynamic #LTP thresholds. The findings suggest astrocytic signaling is crucial for #AdaptiveLearning, linking #glial activity to #behavioral flexibility. Here’s a summary from our JC:

    🌍 fabriziomusacchio.com/blog/202
    📝 doi.org/10.1038/s42003-024-065

    #CompNeuro #Neuroscience

  10. Recently, we discussed this insightful paper by Squadrani et al (2024) in our #JournalClub. It explores how #astrocytes enhance #SynapticPlasticity during #ReversalLearning by modulating D-serine levels, providing a #biophysical basis for dynamic #LTP thresholds. The findings suggest astrocytic signaling is crucial for #AdaptiveLearning, linking #glial activity to #behavioral flexibility. Here’s a summary from our JC:

    🌍 fabriziomusacchio.com/blog/202
    📝 doi.org/10.1038/s42003-024-065

    #CompNeuro #Neuroscience

  11. Recently, we discussed this insightful paper by Squadrani et al (2024) in our #JournalClub. It explores how #astrocytes enhance #SynapticPlasticity during #ReversalLearning by modulating D-serine levels, providing a #biophysical basis for dynamic #LTP thresholds. The findings suggest astrocytic signaling is crucial for #AdaptiveLearning, linking #glial activity to #behavioral flexibility. Here’s a summary from our JC:

    🌍 fabriziomusacchio.com/blog/202
    📝 doi.org/10.1038/s42003-024-065

    #CompNeuro #Neuroscience

  12. Recently, we discussed this insightful paper by Squadrani et al (2024) in our #JournalClub. It explores how #astrocytes enhance #SynapticPlasticity during #ReversalLearning by modulating D-serine levels, providing a #biophysical basis for dynamic #LTP thresholds. The findings suggest astrocytic signaling is crucial for #AdaptiveLearning, linking #glial activity to #behavioral flexibility. Here’s a summary from our JC:

    🌍 fabriziomusacchio.com/blog/202
    📝 doi.org/10.1038/s42003-024-065

    #CompNeuro #Neuroscience

  13. #Biophysical #principles predict #fitness of #SARS-CoV-2 #variants, Proc Natl Acad Sci USA: pnas.org/doi/abs/10.1073/pnas.

    Our #study sheds light on the impact of specific #mutations on viral fitness and delivers a #tool for predicting the future epidemiological #trajectory of previously unseen or emerging low-frequency variants.

  14. #Biophysical #principles predict #fitness of #SARS-CoV-2 #variants, Proc Natl Acad Sci USA: pnas.org/doi/abs/10.1073/pnas.

    Our #study sheds light on the impact of specific #mutations on viral fitness and delivers a #tool for predicting the future epidemiological #trajectory of previously unseen or emerging low-frequency variants.

  15. #Biophysical #principles predict #fitness of #SARS-CoV-2 #variants, Proc Natl Acad Sci USA: pnas.org/doi/abs/10.1073/pnas.

    Our #study sheds light on the impact of specific #mutations on viral fitness and delivers a #tool for predicting the future epidemiological #trajectory of previously unseen or emerging low-frequency variants.

  16. #Biophysical #principles predict #fitness of #SARS-CoV-2 #variants, Proc Natl Acad Sci USA: pnas.org/doi/abs/10.1073/pnas.

    Our #study sheds light on the impact of specific #mutations on viral fitness and delivers a #tool for predicting the future epidemiological #trajectory of previously unseen or emerging low-frequency variants.

  17. #Biophysical #principles predict #fitness of #SARS-CoV-2 #variants, Proc Natl Acad Sci USA: pnas.org/doi/abs/10.1073/pnas.

    Our #study sheds light on the impact of specific #mutations on viral fitness and delivers a #tool for predicting the future epidemiological #trajectory of previously unseen or emerging low-frequency variants.

  18. Special #seminar this Thursday, 4/4, at noon EST with Jason George from Texas A&M. Dr. George will discuss #biophysical and stochastic modeling of the tumor-immune interaction for optimizing T cell #immunotherapies. And you can join here:

    moffitt.zoom.us/j/91265406655

  19. Special #seminar this Thursday, 4/4, at noon EST with Jason George from Texas A&M. Dr. George will discuss #biophysical and stochastic modeling of the tumor-immune interaction for optimizing T cell #immunotherapies. And you can join here:

    moffitt.zoom.us/j/91265406655

  20. Special #seminar this Thursday, 4/4, at noon EST with Jason George from Texas A&M. Dr. George will discuss #biophysical and stochastic modeling of the tumor-immune interaction for optimizing T cell #immunotherapies. And you can join here:

    moffitt.zoom.us/j/91265406655

  21. Special #seminar this Thursday, 4/4, at noon EST with Jason George from Texas A&M. Dr. George will discuss #biophysical and stochastic modeling of the tumor-immune interaction for optimizing T cell #immunotherapies. And you can join here:

    moffitt.zoom.us/j/91265406655

  22. Special #seminar this Thursday, 4/4, at noon EST with Jason George from Texas A&M. Dr. George will discuss #biophysical and stochastic modeling of the tumor-immune interaction for optimizing T cell #immunotherapies. And you can join here:

    moffitt.zoom.us/j/91265406655

  23. A new paper proposes a #framework—the #PlanetaryCommons—which differs from the global #commons framework by including not only globally shared geographic regions but also critical #biophysical systems that regulate the #resilience and state, and therefore #livability, on #Earth. The new planetary commons should create comprehensive #stewardship obligations through Earth system #governance aimed at restoring and strengthening planetary resilience and #justice.

    pnas.org/doi/10.1073/pnas.2301

  24. A new paper proposes a #framework—the #PlanetaryCommons—which differs from the global #commons framework by including not only globally shared geographic regions but also critical #biophysical systems that regulate the #resilience and state, and therefore #livability, on #Earth. The new planetary commons should create comprehensive #stewardship obligations through Earth system #governance aimed at restoring and strengthening planetary resilience and #justice.

    pnas.org/doi/10.1073/pnas.2301

  25. A new paper proposes a #framework—the #PlanetaryCommons—which differs from the global #commons framework by including not only globally shared geographic regions but also critical #biophysical systems that regulate the #resilience and state, and therefore #livability, on #Earth. The new planetary commons should create comprehensive #stewardship obligations through Earth system #governance aimed at restoring and strengthening planetary resilience and #justice.

    pnas.org/doi/10.1073/pnas.2301