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Enhancement of OVA-induced murine lung eosinophilia by co-exposure to contamination levels of #LPS in Asian sand #dust and heated dust

Yahao Ren, et al.
Published: 2014 Jun 9

"A previous study has shown that the aggravation of Asian sand dust (ASD) on ovalbumin (OVA)-induced lung eosinphilia was more severe in lipopolysaccharide (LPS)-rich ASD than in SiO2-rich ASD. Therefore, the effects of different LPS contamination levels in ASD on the aggravation of OVA-induced lung eosinophilia were investigated in the present study.

Conclusions:

"This study demonstrates that LPS contamination in ASD aggravates allergic lung inflammation in the presence of OVA and H-ASD. The aggravation of the allergic lung inflammation by LPS may be caused through the TLR4-dependent signaling pathway. The results of the current study indicate that the exposure to ASD with LPS may be a significant risk factor for adult and child #asthma. The hazardous effects of #MineralDust and #biogenic agents on human respiratory disease are an increasing public concern. Atmospheric exposure to #bacteria, fungi and virus, and silica-carrying particulate matters may influence human respiratory health on a world-wide scale."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058696/

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