#ampk — Public Fediverse posts

Ergothioneine: The Long Neglected Nutrient for Healthy Ageing | Professor Barry Halliwell | NUS Medicine
20 Feb 2025
https://youtu.be/C3WdAWzIuUo

Introductory talk is on #hemin as an #AMPK activator

#aging #health #ergothioneine #NaturalProducts #FunctionalFoods #mushrooms

Ergothioneine: The Long Neglected Nutrient for Healthy Ageing | Professor Barry Halliwell | NUS Medicine
20 Feb 2025
https://youtu.be/C3WdAWzIuUo

Introductory talk is on #hemin as an #AMPK activator

#aging #health #ergothioneine #NaturalProducts #FunctionalFoods #mushrooms

Ergothioneine: The Long Neglected Nutrient for Healthy Ageing | Professor Barry Halliwell | NUS Medicine
20 Feb 2025
https://youtu.be/C3WdAWzIuUo

Introductory talk is on #hemin as an #AMPK activator

#aging #health #ergothioneine #NaturalProducts #FunctionalFoods #mushrooms

Ergothioneine: The Long Neglected Nutrient for Healthy Ageing | Professor Barry Halliwell | NUS Medicine
20 Feb 2025
https://youtu.be/C3WdAWzIuUo

Introductory talk is on #hemin as an #AMPK activator

#aging #health #ergothioneine #NaturalProducts #FunctionalFoods #mushrooms

“…scientists made a surprising discovery: caffeine doesn’t act on this growth switch directly. Instead, it works by activating another important system called AMPK, a cellular fuel gauge that is evolutionarily conserved in yeast and humans.” #DNA #epigenetics #coffee #ISOGG #geneadons #caffeine #AMPK #MTOR

https://www.qmul.ac.uk/media/news/2025/science-and-engineering/se/caffeine-could-slow-cellular-ageing-new-research-shows-how.html

Another paper about AMPK. This gives a good overview as well as information about AMPK activation.

Takeaway: If you wish you had access to Metformin but don't, you might want to look into what this paper says about AMPK activation.

https://pmc.ncbi.nlm.nih.gov/articles/PMC4039279/

#AMPK #Metformin

#AMPK #Longevity #PublicHealth

Researchers discover how #caffeine could slow cellular #aging
Caffeine has long been linked to potential #health benefits, including reduced risk of age-related diseases. But how it works inside our cells, and what its exact connections are with nutrient and stress-responsive #gene and #protein networks, has remained a mystery—until now. Caffeine doesn't act on this growth switch directly. Instead, it works by activating another important system called #AMPK.
https://phys.org/news/2025-06-caffeine-cellular-aging.html

Caffeine Gives Cells an Energy Boost Against Aging - Neuroscience News (on fission yeast) https://share.google/iuPzX4CREmjQ9dlsa
Very interesting, and it adds complexity to caffeine, but caffeine had also many other effects on #health )
#caffeine #biology #ampk

SciTech Chronicles. . . . . . . . . . . . . . . . . Jan 16, 2025

https://bit.ly/stc011625

#Antiaging #longevity #LCA #bile #AMPK #liver #AMOC #WHOI #climate #fluxes #proxy-based #British #DNA #Durotriges #Dorset #U5b1 #mitochondrial #Alzheimer’s #Parkinson’s #amyloid #Tau #dopamine #Iceland #Bárðarbunga #eqrthquake #swarm #Holuhraun

SciTech Chronicles. . . . . . . . . . . . . . . . . Jan 16, 2025

https://bit.ly/stc011625

#Antiaging #longevity #LCA #bile #AMPK #liver #AMOC #WHOI #climate #fluxes #proxy-based #British #DNA #Durotriges #Dorset #U5b1 #mitochondrial #Alzheimer’s #Parkinson’s #amyloid #Tau #dopamine #Iceland #Bárðarbunga #eqrthquake #swarm #Holuhraun

@ScienceScholar

⬆️ may be relevant to healthy #Aging

#NAD #metabolism #AMPK

An exciting article out in @biorxivpreprint shows that AMPK inhibits autophagy during glucose starvation in U2OS cells.

https://www.biorxiv.org/content/10.1101/2023.09.28.559981v2

Whether glucose starvation induces or inhibits autophagy is a controversial topic, something my lab discovered when we struggled for almost two years to publish our findings that in yeast glucose starvation actually actively suppresses autophagy ten years ago.

https://pubmed.ncbi.nlm.nih.gov/24753258/

#autophagy #AMPK #mTORC1 #CellBiology

A mitochondrial #EglN1/#PHD2-#AMPK-alpha axis drives #breastcancer progression by enhancing metabolic adaptation to #hypoxic stress

#Hypoxia-induced EglN1-#CaMKK2 interaction on #mitochondrial safeguards AMPKα activation and #metabolic homeostasis during breast cancer growth

https://www.embopress.org/doi/full/10.15252/embj.2023113743

A mitochondrial #EglN1/#PHD2-#AMPK-alpha axis drives #breastcancer progression by enhancing metabolic adaptation to #hypoxic stress

#Hypoxia-induced EglN1-#CaMKK2 interaction on #mitochondrial safeguards AMPKα activation and #metabolic homeostasis during breast cancer growth

https://www.embopress.org/doi/full/10.15252/embj.2023113743

A mitochondrial #EglN1/#PHD2-#AMPK-alpha axis drives #breastcancer progression by enhancing metabolic adaptation to #hypoxic stress

#Hypoxia-induced EglN1-#CaMKK2 interaction on #mitochondrial safeguards AMPKα activation and #metabolic homeostasis during breast cancer growth

https://www.embopress.org/doi/full/10.15252/embj.2023113743

A mitochondrial #EglN1/#PHD2-#AMPK-alpha axis drives #breastcancer progression by enhancing metabolic adaptation to #hypoxic stress

#Hypoxia-induced EglN1-#CaMKK2 interaction on #mitochondrial safeguards AMPKα activation and #metabolic homeostasis during breast cancer growth

https://www.embopress.org/doi/full/10.15252/embj.2023113743

'These data demonstrate an important physiological role of AMPKβ1 Ser108 phosphorylation in promoting fatty acid oxidation, mitochondrial biogenesis and autophagy under conditions of high lipid availability. As both ketogenic diets and intermittent fasting increase circulating free fatty acid levels, AMPK activity, mitochondrial biogenesis, and mitophagy, these data suggest a potential unifying mechanism which may be important in mediating these effects.'

#Metabolism #AMPK

https://www.pnas.org/doi/10.1073/pnas.2119824119