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#2p — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #2p, aggregated by home.social.

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  1. Nice #Labrigger post on a point that is easy to forget in #2p #CalciumImaging: Image quality is not just about seeing cells, but about photons/s/neuron.

    Larger FOVs are tempting, but they usually mean fewer #photons per cell, lower sensitivity to small Delta F/F events, and more trouble w/ #neuropil contamination. In the end, fidelity is a measurement problem, not just an optics problem:

    labrigger.com/blog/2026/07/25/

    #TwoPhoton #Neuroscience

  2. Nice #Labrigger post on a point that is easy to forget in #2p #CalciumImaging: Image quality is not just about seeing cells, but about photons/s/neuron.

    Larger FOVs are tempting, but they usually mean fewer #photons per cell, lower sensitivity to small Delta F/F events, and more trouble w/ #neuropil contamination. In the end, fidelity is a measurement problem, not just an optics problem:

    labrigger.com/blog/2026/07/25/

    #TwoPhoton #Neuroscience

  3. Nice #Labrigger post on a point that is easy to forget in #2p #CalciumImaging: Image quality is not just about seeing cells, but about photons/s/neuron.

    Larger FOVs are tempting, but they usually mean fewer #photons per cell, lower sensitivity to small Delta F/F events, and more trouble w/ #neuropil contamination. In the end, fidelity is a measurement problem, not just an optics problem:

    labrigger.com/blog/2026/07/25/

    #TwoPhoton #Neuroscience

  4. Nice #Labrigger post on a point that is easy to forget in #2p #CalciumImaging: Image quality is not just about seeing cells, but about photons/s/neuron.

    Larger FOVs are tempting, but they usually mean fewer #photons per cell, lower sensitivity to small Delta F/F events, and more trouble w/ #neuropil contamination. In the end, fidelity is a measurement problem, not just an optics problem:

    labrigger.com/blog/2026/07/25/

    #TwoPhoton #Neuroscience

  5. Nice #Labrigger post on a point that is easy to forget in #2p #CalciumImaging: Image quality is not just about seeing cells, but about photons/s/neuron.

    Larger FOVs are tempting, but they usually mean fewer #photons per cell, lower sensitivity to small Delta F/F events, and more trouble w/ #neuropil contamination. In the end, fidelity is a measurement problem, not just an optics problem:

    labrigger.com/blog/2026/07/25/

    #TwoPhoton #Neuroscience

  6. Designing a board game that works well for exactly two players is a very different challenge from designing one that supports a range of player counts. Many games include a two-player mode, but board games such as Patchwork and Jaipur show that a dedicated head-to-head experience can be unique and not simply an adapted and reduced version of a game that is really aimed at larger player counts. In this article, I want to look at the design challenge these dedicated two-player-only games present.

    Read the full article here: tabletopgamesblog.com/2026/07/
    Listen to the audio version here: open.spotify.com/episode/6RRCy

    (Photo by Planet Volumes on Unsplash)

    #boardgames #TwoPlayers #2p #duels #TwoPlayerGames

  7. Designing a board game that works well for exactly two players is a very different challenge from designing one that supports a range of player counts. Many games include a two-player mode, but board games such as Patchwork and Jaipur show that a dedicated head-to-head experience can be unique and not simply an adapted and reduced version of a game that is really aimed at larger player counts. In this article, I want to look at the design challenge these dedicated two-player-only games present.

    Read the full article here: tabletopgamesblog.com/2026/07/
    Listen to the audio version here: open.spotify.com/episode/6RRCy

    (Photo by Planet Volumes on Unsplash)

    #boardgames #TwoPlayers #2p #duels #TwoPlayerGames

  8. Designing a board game that works well for exactly two players is a very different challenge from designing one that supports a range of player counts. Many games include a two-player mode, but board games such as Patchwork and Jaipur show that a dedicated head-to-head experience can be unique and not simply an adapted and reduced version of a game that is really aimed at larger player counts. In this article, I want to look at the design challenge these dedicated two-player-only games present.

    Read the full article here: tabletopgamesblog.com/2026/07/
    Listen to the audio version here: open.spotify.com/episode/6RRCy

    (Photo by Planet Volumes on Unsplash)

    #boardgames #TwoPlayers #2p #duels #TwoPlayerGames

  9. Hi, it's Joe Slack here. Oliver was kind enough to allow me to write another guest blog. In this article, I thought it would be interesting to discuss board games for two and the gaming experience for two people (especially couples).

    Read the full article here: tabletopgamesblog.com/2026/06/
    Listen to the audio version here: open.spotify.com/episode/7gOEx

    (Photo by Big Potato on Unsplash)

    #boardgames #TwoPlayer #2p #2Player #couples

  10. Hi, it's Joe Slack here. Oliver was kind enough to allow me to write another guest blog. In this article, I thought it would be interesting to discuss board games for two and the gaming experience for two people (especially couples).

    Read the full article here: tabletopgamesblog.com/2026/06/
    Listen to the audio version here: open.spotify.com/episode/7gOEx

    (Photo by Big Potato on Unsplash)

    #boardgames #TwoPlayer #2p #2Player #couples

  11. Hi, it's Joe Slack here. Oliver was kind enough to allow me to write another guest blog. In this article, I thought it would be interesting to discuss board games for two and the gaming experience for two people (especially couples).

    Read the full article here: tabletopgamesblog.com/2026/06/
    Listen to the audio version here: open.spotify.com/episode/7gOEx

    (Photo by Big Potato on Unsplash)

    #boardgames #TwoPlayer #2p #2Player #couples

  12. The pub was quiet after the lunchtime rush. It was a chilly autumn afternoon, so the hearty lunch just hit the spot. Now we were sitting there, playing a card game, with a pint each by our sides. While the meal had filled us up, we still fancied something savoury. We just needed a small snack that the two of us could share. Nothing fancy. Something simple would do. Of course, it had to be Crisps! by Shreesh Bhat from Little Dog Games with art by Sai Beppu.

    Read the full review here: tabletopgamesblog.com/2026/05/
    Listen to the audio version here: open.spotify.com/episode/2qdhj

    #boardgames #CardGames #SheddingGames #2PlayerGames #2p

  13. The pub was quiet after the lunchtime rush. It was a chilly autumn afternoon, so the hearty lunch just hit the spot. Now we were sitting there, playing a card game, with a pint each by our sides. While the meal had filled us up, we still fancied something savoury. We just needed a small snack that the two of us could share. Nothing fancy. Something simple would do. Of course, it had to be Crisps! by Shreesh Bhat from Little Dog Games with art by Sai Beppu.

    Read the full review here: tabletopgamesblog.com/2026/05/
    Listen to the audio version here: open.spotify.com/episode/2qdhj

    #boardgames #CardGames #SheddingGames #2PlayerGames #2p

  14. The pub was quiet after the lunchtime rush. It was a chilly autumn afternoon, so the hearty lunch just hit the spot. Now we were sitting there, playing a card game, with a pint each by our sides. While the meal had filled us up, we still fancied something savoury. We just needed a small snack that the two of us could share. Nothing fancy. Something simple would do. Of course, it had to be Crisps! by Shreesh Bhat from Little Dog Games with art by Sai Beppu.

    Read the full review here: tabletopgamesblog.com/2026/05/
    Listen to the audio version here: open.spotify.com/episode/2qdhj

    #boardgames #CardGames #SheddingGames #2PlayerGames #2p

  15. 🧠New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury. #Neuroscience

    Intravital calcium imaging of ...

  16. 🧠New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury. #Neuroscience

    Intravital calcium imaging of ...

  17. 🧠New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury. #Neuroscience

    Intravital calcium imaging of ...

  18. 🧠New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury. #Neuroscience

    Intravital calcium imaging of ...

  19. 🧠New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury. #Neuroscience

    Intravital calcium imaging of ...

  20. 🐭🎶 New paper by Isko et al, who study #Alston’s singing mouse, a rodent with loud, stereotyped songs.

    Using bulk tracing, serial #2P #tomography, & #MAPseq of >76,000 barcoded neurons, they find expanded projections from #orofacial #MotorCortex to #auditory #cortex & #PAG. This suggests that singing / #Vocalization may emerge not from entirely new circuits, but from selective strengthening of existing motor, auditory & vocal-control pathways.

    📝 doi.org/10.1038/s41586-026-104

    #Neuroscience #Evolution

  21. 🐭🎶 New paper by Isko et al, who study #Alston’s singing mouse, a rodent with loud, stereotyped songs.

    Using bulk tracing, serial #2P #tomography, & #MAPseq of >76,000 barcoded neurons, they find expanded projections from #orofacial #MotorCortex to #auditory #cortex & #PAG. This suggests that singing / #Vocalization may emerge not from entirely new circuits, but from selective strengthening of existing motor, auditory & vocal-control pathways.

    📝 doi.org/10.1038/s41586-026-104

    #Neuroscience #Evolution

  22. 🐭🎶 New paper by Isko et al, who study #Alston’s singing mouse, a rodent with loud, stereotyped songs.

    Using bulk tracing, serial #2P #tomography, & #MAPseq of >76,000 barcoded neurons, they find expanded projections from #orofacial #MotorCortex to #auditory #cortex & #PAG. This suggests that singing / #Vocalization may emerge not from entirely new circuits, but from selective strengthening of existing motor, auditory & vocal-control pathways.

    📝 doi.org/10.1038/s41586-026-104

    #Neuroscience #Evolution

  23. 🐭🎶 New paper by Isko et al, who study #Alston’s singing mouse, a rodent with loud, stereotyped songs.

    Using bulk tracing, serial #2P #tomography, & #MAPseq of >76,000 barcoded neurons, they find expanded projections from #orofacial #MotorCortex to #auditory #cortex & #PAG. This suggests that singing / #Vocalization may emerge not from entirely new circuits, but from selective strengthening of existing motor, auditory & vocal-control pathways.

    📝 doi.org/10.1038/s41586-026-104

    #Neuroscience #Evolution

  24. 🐭🎶 New paper by Isko et al, who study #Alston’s singing mouse, a rodent with loud, stereotyped songs.

    Using bulk tracing, serial #2P #tomography, & #MAPseq of >76,000 barcoded neurons, they find expanded projections from #orofacial #MotorCortex to #auditory #cortex & #PAG. This suggests that singing / #Vocalization may emerge not from entirely new circuits, but from selective strengthening of existing motor, auditory & vocal-control pathways.

    📝 doi.org/10.1038/s41586-026-104

    #Neuroscience #Evolution

  25. 🔬 New #SpectralUnmixing paper by Ashesh et al. ( @florianjug): A #DeepLearning-based framework #MicroSplit for #FluorescenceMicroscopy that separates highly overlapping #fluorophore signals directly from multiplexed #ImagingData. Improves signal separation, reduces crosstalk, & enables more accurate multi-channel #imaging w/o requiring extensive reference measurements. Can’t wait to try this out on our in vivo #2P/ #3P imaging data:

    📝 doi.org/10.1038/s41592-026-030

    #Bioimaging

  26. 🔬 New #SpectralUnmixing paper by Ashesh et al. ( @florianjug): A #DeepLearning-based framework #MicroSplit for #FluorescenceMicroscopy that separates highly overlapping #fluorophore signals directly from multiplexed #ImagingData. Improves signal separation, reduces crosstalk, & enables more accurate multi-channel #imaging w/o requiring extensive reference measurements. Can’t wait to try this out on our in vivo #2P/ #3P imaging data:

    📝 doi.org/10.1038/s41592-026-030

    #Bioimaging

  27. 🔬 New #SpectralUnmixing paper by Ashesh et al. ( @florianjug): A #DeepLearning-based framework #MicroSplit for #FluorescenceMicroscopy that separates highly overlapping #fluorophore signals directly from multiplexed #ImagingData. Improves signal separation, reduces crosstalk, & enables more accurate multi-channel #imaging w/o requiring extensive reference measurements. Can’t wait to try this out on our in vivo #2P/ #3P imaging data:

    📝 doi.org/10.1038/s41592-026-030

    #Bioimaging

  28. 🔬 New #SpectralUnmixing paper by Ashesh et al. ( @florianjug): A #DeepLearning-based framework #MicroSplit for #FluorescenceMicroscopy that separates highly overlapping #fluorophore signals directly from multiplexed #ImagingData. Improves signal separation, reduces crosstalk, & enables more accurate multi-channel #imaging w/o requiring extensive reference measurements. Can’t wait to try this out on our in vivo #2P/ #3P imaging data:

    📝 doi.org/10.1038/s41592-026-030

    #Bioimaging

  29. 🔬 New #SpectralUnmixing paper by Ashesh et al. ( @florianjug): A #DeepLearning-based framework #MicroSplit for #FluorescenceMicroscopy that separates highly overlapping #fluorophore signals directly from multiplexed #ImagingData. Improves signal separation, reduces crosstalk, & enables more accurate multi-channel #imaging w/o requiring extensive reference measurements. Can’t wait to try this out on our in vivo #2P/ #3P imaging data:

    📝 doi.org/10.1038/s41592-026-030

    #Bioimaging

  30. #2P #Xploria online: Diagnosegestützt fördern in #Deutsch und #DaZ

    Freischalten, Lernstände einsehen, Aufträge zuweisen – erklären und sofort praktisch umgesetzt.
    Plus: Umgang mit Schüler-Logins und Austausch mit 2P-Expertinnen und Experten

    Digitale Infoveranstaltung zu 2P Sekundar – Lerntool Xploria Deutsch und DaZ am 20. Mai 2026 von 13:30 bis 17:30 Uhr

  31. #2P #Xploria online: Diagnosegestützt fördern in #Deutsch und #DaZ

    Freischalten, Lernstände einsehen, Aufträge zuweisen – erklären und sofort praktisch umgesetzt.
    Plus: Umgang mit Schüler-Logins und Austausch mit 2P-Expertinnen und Experten

    Digitale Infoveranstaltung zu 2P Sekundar – Lerntool Xploria Deutsch und DaZ am 20. Mai 2026 von 13:30 bis 17:30 Uhr

  32. #2P #Xploria online: Diagnosegestützt fördern in #Deutsch und #DaZ

    Freischalten, Lernstände einsehen, Aufträge zuweisen – erklären und sofort praktisch umgesetzt.
    Plus: Umgang mit Schüler-Logins und Austausch mit 2P-Expertinnen und Experten

    Digitale Infoveranstaltung zu 2P Sekundar – Lerntool Xploria Deutsch und DaZ am 20. Mai 2026 von 13:30 bis 17:30 Uhr

  33. 🧠 New preprint by Kim et al. (2025) from David Anderson’s lab: A line #attractor maintains aggressiveness during feeding in “hangry” mice 🍔🐁. Using in vivo #CalciumImaging and #rSLDS modeling, they show how moderate fasting stabilizes an aggression-related attractor in #VMHvl, while prolonged fasting collapses it, linking hunger, motivation, and aggression through #PopulationDynamics:

    🌍 doi.org/10.1101/2025.10.16.682

    #Neuroscience #CompNeuro #Behavior #AttractorDynamics #Hypothalamus #2p #imaging

  34. 🧠 New preprint by Kim et al. (2025) from David Anderson’s lab: A line #attractor maintains aggressiveness during feeding in “hangry” mice 🍔🐁. Using in vivo #CalciumImaging and #rSLDS modeling, they show how moderate fasting stabilizes an aggression-related attractor in #VMHvl, while prolonged fasting collapses it, linking hunger, motivation, and aggression through #PopulationDynamics:

    🌍 doi.org/10.1101/2025.10.16.682

    #Neuroscience #CompNeuro #Behavior #AttractorDynamics #Hypothalamus #2p #imaging

  35. 🧠 New preprint by Kim et al. (2025) from David Anderson’s lab: A line #attractor maintains aggressiveness during feeding in “hangry” mice 🍔🐁. Using in vivo #CalciumImaging and #rSLDS modeling, they show how moderate fasting stabilizes an aggression-related attractor in #VMHvl, while prolonged fasting collapses it, linking hunger, motivation, and aggression through #PopulationDynamics:

    🌍 doi.org/10.1101/2025.10.16.682

    #Neuroscience #CompNeuro #Behavior #AttractorDynamics #Hypothalamus #2p #imaging

  36. 🧠 New preprint by Kim et al. (2025) from David Anderson’s lab: A line #attractor maintains aggressiveness during feeding in “hangry” mice 🍔🐁. Using in vivo #CalciumImaging and #rSLDS modeling, they show how moderate fasting stabilizes an aggression-related attractor in #VMHvl, while prolonged fasting collapses it, linking hunger, motivation, and aggression through #PopulationDynamics:

    🌍 doi.org/10.1101/2025.10.16.682

    #Neuroscience #CompNeuro #Behavior #AttractorDynamics #Hypothalamus #2p #imaging

  37. 🧠 Rao & Ballard’s (1999) spatial #PredictiveCoding theory gets strong support: Zhang et al. (2025) show in mouse #VisualCortex that predictive coding is primarily spatial, not temporal. #2P #imaging of ~20,000 neurons found mismatch responses only when new spatial landmarks appeared, but not when sequences were reordered:

    🌍 doi.org/10.1101/2025.09.17.676

    #Neuroscience

  38. 🧠 Rao & Ballard’s (1999) spatial #PredictiveCoding theory gets strong support: Zhang et al. (2025) show in mouse #VisualCortex that predictive coding is primarily spatial, not temporal. #2P #imaging of ~20,000 neurons found mismatch responses only when new spatial landmarks appeared, but not when sequences were reordered:

    🌍 doi.org/10.1101/2025.09.17.676

    #Neuroscience

  39. 🧠 Rao & Ballard’s (1999) spatial #PredictiveCoding theory gets strong support: Zhang et al. (2025) show in mouse #VisualCortex that predictive coding is primarily spatial, not temporal. #2P #imaging of ~20,000 neurons found mismatch responses only when new spatial landmarks appeared, but not when sequences were reordered:

    🌍 doi.org/10.1101/2025.09.17.676

    #Neuroscience