home.social

#estimands — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #estimands, aggregated by home.social.

  1. Why this matters

    1️⃣ Clear estimand – the target of inference is defined up front, removing ambiguity.
    2️⃣ Transparent causality – DAGs & SWIGs show which confounding pathways are blocked.
    3️⃣ Step by step DER – our dose exposure response derivation give the standard workflow familiar to all pharmacometricians.

    #Estimands #DoseFinding

    2/6

  2. I think this is a next/ remaining frontier for pragmatic #RCTs in this area and the concept of #Estimands could potentially help here, as an approach to link several elements for trial and intervention planning
    jpro.springeropen.com/articles

    While the intervention should not be planned to fit a trial, it is clearly possible to develop an intervention with an outcome in mind and theorise about the direction and size/relevance of expected effects.