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  1. @justinwilkins @damiacer

    That's what I was thinking. I think #nlmixr2 would fit right in there. Do you know folks at Roche? We should approach them.

  2. @justinwilkins @damiacer

    That's what I was thinking. I think #nlmixr2 would fit right in there. Do you know folks at Roche? We should approach them.

  3. - It is also validated against the / model so you know if it is working immediately

  4. Want a single language for a few pharmcometric applications? How about giving #babelmixr2, an extension of #nlmixr2 a try?

  5. I would like to mention a new release of . I haven't posted about it but I would like to mention my favorite new features:

  6. would like to mention a new release of #nlmixr2. I haven't posted about it but I would like to mention my favorite new features:

  7. would like to mention a new release of #nlmixr2. I haven't posted about it but I would like to mention my favorite new features:

  8. would like to mention a new release of #nlmixr2. I haven't posted about it but I would like to mention my favorite new features:

  9. Hi everyone! This is the official home of on Mastodon. We are a constellation of packages aimed at supporting easy and robust nonlinear mixed-effects models in R. We are free and and will be forever.

    Stay tuned for announcements of blog postings, chat, trivia, and whatever you all want to talk about!

    nlmixr2.org

  10. Hi everyone! This is the official home of #nlmixr2 on Mastodon. We are a constellation of #rstats packages aimed at supporting easy and robust nonlinear mixed-effects models in R. We are free and #OpenSource and will be forever.

    Stay tuned for announcements of blog postings, chat, trivia, and whatever you all want to talk about!

    #Pharmacometrics

    nlmixr2.org

  11. Hi everyone! This is the official home of #nlmixr2 on Mastodon. We are a constellation of #rstats packages aimed at supporting easy and robust nonlinear mixed-effects models in R. We are free and #OpenSource and will be forever.

    Stay tuned for announcements of blog postings, chat, trivia, and whatever you all want to talk about!

    #Pharmacometrics

    nlmixr2.org

  12. Hi everyone! This is the official home of #nlmixr2 on Mastodon. We are a constellation of #rstats packages aimed at supporting easy and robust nonlinear mixed-effects models in R. We are free and #OpenSource and will be forever.

    Stay tuned for announcements of blog postings, chat, trivia, and whatever you all want to talk about!

    #Pharmacometrics

    nlmixr2.org

  13. Hi everyone! This is the official home of #nlmixr2 on Mastodon. We are a constellation of #rstats packages aimed at supporting easy and robust nonlinear mixed-effects models in R. We are free and #OpenSource and will be forever.

    Stay tuned for announcements of blog postings, chat, trivia, and whatever you all want to talk about!

    #Pharmacometrics

    nlmixr2.org

  14. Modeling tools in our area are largely closed-source and massively expensive, and are a gigantic entry barrier for new people, especially in low and middle-income countries (and borderline unaffordable even for CROs like mine). is intended to be a solution to this problem. I also maintain the package, which provides a handy set of general functions.

    @nlmixr2

    nlmixr2.org

  15. Modeling tools in our area are largely closed-source and massively expensive, and are a gigantic entry barrier for new people, especially in low and middle-income countries (and borderline unaffordable even for CROs like mine). #nlmixr2 is intended to be a solution to this problem. I also maintain the #pmxTools package, which provides a handy set of general #PMx functions.

    @nlmixr2

    nlmixr2.org

  16. Modeling tools in our area are largely closed-source and massively expensive, and are a gigantic entry barrier for new people, especially in low and middle-income countries (and borderline unaffordable even for CROs like mine). #nlmixr2 is intended to be a solution to this problem. I also maintain the #pmxTools package, which provides a handy set of general #PMx functions.

    @nlmixr2

    nlmixr2.org

  17. Modeling tools in our area are largely closed-source and massively expensive, and are a gigantic entry barrier for new people, especially in low and middle-income countries (and borderline unaffordable even for CROs like mine). #nlmixr2 is intended to be a solution to this problem. I also maintain the #pmxTools package, which provides a handy set of general #PMx functions.

    @nlmixr2

    nlmixr2.org

  18. New features in #nlmixr2 4.0, a #rstats package include a vere-style loading, importing models from older versions of nlmixr2 and Rstudio bug fixes. See blog.nlmixr2.org/blog/2025-08-

  19. We have a new nlmixr2 blog entry courtesy of Hitesh Mistry and Nicola Melillo (@NicolaMelillo) detailing how to upscale nlmixr2 using AWS. This is helpful for long running SAEM models. In the future it may be even more interesting with other methods parallelized. (#nlmixr2 #rstats)

    blog.nlmixr2.org/blog/2024-03-

  20. New from the R Consortium nlmixr2 Working Group:

    The nlmixr2 Working Group is expanding what open-source R tooling can support in pharmacometrics, including time-to-event modeling workflows that are important in clinical and drug-development settings.

    This new post highlights technical work from Justin Wilkins and the nlmixr2 Development Team on fitting parametric time-to-event models in nlmixr2.

    Read more:
    r-consortium.org/posts/surviva

  21. Latest from the new R Consortium nlmixr2 Working Group:

    nlmixr2—an R-based, open-source nonlinear mixed-effects modeling package that can compete with commercial pharmacometrics tools and support regulatory submissions—now supports inter-occasion variability (IOV).

    Read the full details in their newest blog post:
    r-consortium.org/posts/from-nl

  22. - It is also validated against the #nlmixr2 / #rxode2 model so you know if it is working immediately

  23. We are excited to announce a new feature in nlmixr2: mceta for FOCEi. This is a hybrid approach combines Monte-Carlo sampling with the classical FOCEi algorithm bringing flexibility & robustness to nonlinear mixed-effects modeling in pharmacometrics. #nlmixr2 #rstats

  24. In this month's Blog, I discuss a new feature in the nlmixr2 ecosystem (in babelmixr2) -- translating and using nlmixr2 models in optimal design. They are fast and easy to use making this my go to tool when doing optimal design. #nlmixr2 #rstats

    blog.nlmixr2.org/blog/2024-11-

  25. Want a single language for a few pharmcometric applications? How about giving , an extension of a try?

  26. Want a single language for a few pharmcometric applications? How about giving #babelmixr2, an extension of #nlmixr2 a try?

  27. I'm on fosstodon.org because I do a lot of development, most notably as a member of the development team. nlmixr2 is a set of packages - let's call it the - for R that provides an alternative for nonlinear mixed-effects () model development, which are the core of most workflows (amongst others).

  28. I'm on fosstodon.org because I do a lot of #rstats development, most notably as a member of the #nlmixr2 development team. nlmixr2 is a set of packages - let's call it the #mixrverse - for R that provides an #OpenSource alternative for nonlinear mixed-effects (#NLME) model development, which are the core of most #Pharmacometrics workflows (amongst others).

  29. I'm on fosstodon.org because I do a lot of #rstats development, most notably as a member of the #nlmixr2 development team. nlmixr2 is a set of packages - let's call it the #mixrverse - for R that provides an #OpenSource alternative for nonlinear mixed-effects (#NLME) model development, which are the core of most #Pharmacometrics workflows (amongst others).

  30. I'm on fosstodon.org because I do a lot of #rstats development, most notably as a member of the #nlmixr2 development team. nlmixr2 is a set of packages - let's call it the #mixrverse - for R that provides an #OpenSource alternative for nonlinear mixed-effects (#NLME) model development, which are the core of most #Pharmacometrics workflows (amongst others).