Search
22 results for “seps”
-
🚨 Today we published our #OpenSource AI model for the early detection of sepsis in the world's leading journal of laboratory medicine!🚨
Discovering sepsis patients sooner (=saving lives) is now possible with just a bit of routine lab data
Article:
https://doi.org/10.1093/clinchem/hvae001Press release of the University Hospital Leipzig [German]:
https://www.uniklinikum-leipzig.de/presse/Seiten/Pressemitteilung_7850.aspxPress release [English]:
https://www.uniklinikum-leipzig.de/einrichtungen/ampel/en/Pages/sepsis_press_release.aspx#Sepsis #SepsisAwareness #DeutschlandErkenntSepsis #GemeinsamGegenSepsis #GetAheadOfSepsis
-
Delayed sepsis detection increases mortality risk. How can #MedicalAI assist us here?
In the #AMPEL project, we extensively researched this over years using multicenter data from Germany and the USA. The results of our #OpenSource #AI basic model, based only on few parameters of the complete #BloodCount (CBC), exceeded expectations:
[1/2]
#Sepsis #SepsisAwareness #DeutschlandErkenntSepsis #GemeinsamGegenSepsis #GetAheadOfSepsis
-
Erkennung und Behandlung von Sepsis thematisiert #Gesundheitspolitik #Anfrage #Bundestag Erkennung und Behandlung von Sepsis in Deutschland thematisiert die Fraktion Bündnis 90/Die Grünen in einer Kleinen Anfrage. https://www.bundestag.de/1209824
-
https://www.europesays.com/ro/289906/ După Sepsi, și Csikszereda și-a luat-o rău în Liga 1: 5-1 #Csikszereda #FotbalIntern #RO #Română #Romania #Romanian #Sepsi #Sport #Sports
-
NOW ON VERDANT SQUARE RADIO ==
NOW PLAYING == Chewed Up 8/5/26: Danielle Sepsy's perfect chocolate chip cookieshttps://youtu.be/YuQHUo6czfo?si=ou7XZpFEMAq22G9L#arts #peace #food #cooking #radio #resist #vsn #ChewedUp #MichaelSymon #CarlaHall #ClintonKelly #TheChew #DiverseSpectrumOfTheLeft #SupportIndependentMedia
https://mastodon.social/@VerdantSquareRadio/117081899696682679
#news #arts #left #commentary #radio #publicradio #community #progressive #green #kyndmix #vsn
-
⚽#CFRCluj, debut cu victorie în grupele Cupei României: 3-1 cu Sepsi OSK #SfântuGheorghe.
Primele rezultate ale zilei.#Știri #România #Cluj #Covasna #SfântuGheorghe #ȚinutulSecuiesc #Covasna #Transilvania #Cluj #Sport #Fotbal
-
The parents of Ismael Ayala-Uribe, who died of sepsis in ICE custody last September, have filed a wrongful death suit against the agency. They also name the owner of the private prison where he was held and the health care contractor they brought in as defendants.
The lawsuit alleges that, for weeks, Ayala-Uribe complained of “intense and progressive physical pain, including abdominal pain, severe buttock pain, persistent fever, chills, extreme weakness, and continuous intestinal internal pain related to internal bleeding” and that all he ever got was a "cursory assessment" and some over-the-counter pain meds.
ICE, classy as ever, issued a "Detainee Death Report" that leads not with the circumstances of Ayala-Uribe's death, but rather with his crime of being born in the wrong place and the fact that he had a couple of DUI convictions, most recently six years earlier, as though these make a slow, painful death in their custody seem reasonable.
#FuckICE #ICE #ReneeGood #fascism #Necropolitics #DeathInCustody
-
Nextcloud jako osobní cloud
Už 7 let používám Nextcloud pro osobní potřeby. V článku jsem sepsal, na jaké věci jej používám a jaké s nimi mám zkušenosti.
#caldav #carddav #chat #cloud #Collabora #dokumenty #Dropbox #fotky #kalendáře #kontakty #libreoffice #Nextcloud #RSS #úkoly
https://blog.eischmann.cz/2023/11/16/nextcloud-jako-osobni-cloud/
-
NOW ON VERDANT SQUARE RADIO ==
NOW PLAYING == Chewed Up 8/3/26: This strawberry lemonade loaf is pure summer ft. Danielle Sepsyhttps://youtu.be/Ws_jZFZuvvA?si=Z9ANO5aWdiAog1Do#arts #peace #food #cooking #radio #resist #vsn #ChewedUp #MichaelSymon #CarlaHall #ClintonKelly #TheChew #DiverseSpectrumOfTheLeft #SupportIndependentMedia
https://mastodon.social/@VerdantSquareRadio/117031323955193824
#news #arts #left #commentary #radio #publicradio #community #progressive #green #kyndmix
-
Schreibt es auf, verdammte Axt!
https://staude.net/alles-ist-gebackupt-nur-der-zugriff-nicht/Es kann jedem und jeder von uns von einem auf den anderen Moment etwas passieren. In so einem Maß, dass wir nicht mehr Meister:in unseres Oberstübchens sind oder in ein (künstliches) Koma versetzt werden. Sei es, durch eine Erkrankung, einen Unfall, eine OP oder einfach eine Wunde, die sich entzündet, wie bei @staude
Neben Verfügungen und Vollmachten ist wichtig, dass wir verständlich aufschreiben, welche Dienste, Verträge, Zugänge, und Vermögenskonten es gibt.
Dazu gehören auch Wege, wie andere grundlegend dran kommen und es bedienen können. So, dass Dritte das können, ohne uns zu befragen. Niemand kann uns im Fall der Fälle in den Kopf schauen. Was nicht dokumentiert ist, existiert im Zweifel nicht!
#zugang #passwort #sicherheit #patientenverfügung #vorsorgevollmacht #kontovollmacht #notfall #koma #sepsis #tod #nachlass #krankheit #koma
-
@fabio Also due to these regulations I cannot buy antibiotic ointment when the Czech regime is depriving me of healthcare when I have an infected eczema and am afraid it will produce sepsis and I die, because antibiotic ointment ran out and when I call a dermatologist and tell I need it urgently she gives me an appointment 4 months (!!!) in the future!
In a corrupt developing 3rd world dictatorship Cambodia it is possible to buy antibiotic ointments without prescription and also dermatologist wait there is only 7-10 days, not 4 months.
I feel
e x t r e m e l y s t r o n g c o n t e m p t
towards the Czech regime.
#healthdeprivation #deprivation #czech #czechia #czechregime #czechrepublic #failedstate #contempt #regulations #overregulation #bureaucracy #overbureaucratization #healthcaresystem #healthcare #antibiotic #prescription #otc #overthecounter #ointment #eczema #infection #infected #sepsis #death #lethal #dangerous #danger #hazard #risk #eu #deathbybureaucracy #deathbyregulation #kafkaesque #humanrights #humanrightsviolation #humanrightsviolations #righttohealth #humanrighttohealth #basichumanrighttohealth
-
My #BestNine / #TopNine Instagram posts of 2022.
Clockwise from top left:
#DavidBowie (x2)
#IggyPop
#JeffBuckley
#BrianEno
#GeorgeMartin
#SydBarrett
#TomWaitsIn the centre is #SavitaHalappanavar, who died of sepsis in Galway in 2012 when she was refused an abortion for an unviable pregnancy.
Her death gave focus to the pro-abortion campaign in Ireland, ultimately leading to the 2018 referendum that repealed the 8th amendment.
I drew Savita when #RoeVWade was overturned by #Dobbs in June.
-
#introduction to my new #MedMastodon server: I’m a critical care nephrologist, outcomes researcher and #extracorporeal therapies expert but in KIDS 🙃 🦄 😍
#sepsis #fluids #AKI #CriticalCareNephrology #CRRT #ECMO #PedsICU @PPETS -
K polsko-běloruské krizi se toho dnes na plénu Evropského parlamentu řeklo mnoho. Já k tomu od vás stále dostávám spoustu dotazů, sepsala jsem tedy situaci i návrhy řešení do jednoho uceleného textu:
https://gregorova.eu/reseni-krize-na-polskych-hranicich-ma-nekolik-kroku-prvni-musi-vest-k-zachrane-holych-zivotu/ #Belorusko #Lukasenko -
Cześć wam.
Już 5 raz z #wosp
To jest moja eskarbonka wolontariusza.
Jak chcecie, to możecie mi coś wpłacić.
#31finał #wosp2023 będzie 29 stycznia 2023.
W tym roku zbieramy na leczenie sepsy.
#pomagamy #wolontariusz #kwesta
eskarbonka.wosp.org.pl/2e37bx -
Cześć wam.
Już 5 raz z #wosp
To jest moja eskarbonka wolontariusza.
Jak chcecie, to możecie mi coś wpłacić.
#31finał #wosp2023 będzie 29 stycznia 2023.
W tym roku zbieramy na leczenie sepsy.
#pomagamy #wolontariusz #kwesta
https://eskarbonka.wosp.org.pl/2e37bx -
Sign Relations • Semiotic Equivalence Relations 1.2
• https://inquiryintoinquiry.com/2025/12/30/sign-relations-semiotic-equivalence-relations-1-c/A nice property of the sign relations L_A and L_B is that their connotative components Con(L_A) and Con(L_B) form a pair of equivalence relations on their common syntactic domain S = I. This type of equivalence relation is called a “semiotic equivalence relation” (SER) because it equates signs having the same meaning to some interpreter.
Each of the semiotic equivalence relations, Con(L_A), Con(L_B) ⊆ S×I ≅ S×S partitions the collection of signs into semiotic equivalence classes. This constitutes a strong form of representation in that the structure of the interpreters' common object domain {A, B} is reflected or reconstructed, part for part, in the structure of each one's semiotic partition of the syntactic domain {“A”, “B”, “i”, “u”}.
It's important to observe the semiotic partitions for interpreters A and B are not identical, indeed, they are “orthogonal” to each other. Thus we may regard the “form” of the partitions as corresponding to an objective structure or invariant reality, but not the literal sets of signs themselves, independent of the individual interpreter's point of view.
Information about the contrasting patterns of semiotic equivalence corresponding to the interpreters A and B is summarized in Tables 7a and 7b. The form of the Tables serves to explain what is meant by saying the SEPs for A and B are “orthogonal” to each other.
Tables 7a and 7b. Semiotic Partitions for Interpreters A and B
• https://inquiryintoinquiry.com/wp-content/uploads/2025/12/semiotic-partitions-for-interpreters-a-b-2.0.pngSurvey of Semiotics, Semiosis, Sign Relations
• https://inquiryintoinquiry.com/2025/05/06/survey-of-semiotics-semiosis-sign-relations-6/#Peirce #Inquiry #Logic #Mathematics #RelationTheory
#Semiosis #Semiotics #SignRelations #TriadicRelations -
[repost Aborcyjny Dream Team] 24 maja 2023 roku w szpitalu imienia Jana Pawła II zmarła 33-letnia Dorota. Była w piątym miesiącu ciąży. Jak mówi jej mąż: Dorota chciała być matką, ale nie za wszelką cenę.
Dorota leżała przez trzy doby, z nogami w górze i głową w dole — brzmi jak tortury, a nie nowoczesna opieka medyczna. W poniedziałek zaczęła odczuwać silny ból głowy. Małżeństwo nie czuło się dobrze zaopiekowane w szpitalu w Nowym Targu. Mąż Doroty opowiada w programie „Uwaga” w TVN, że próbowali wypisać się na własne żądanie i przenieść się do szpitala w Bochni, ale po rozmowie ze szpitalnym psychologiem postanowili zostać.
Ból głowy u Doroty postępował, a wskaźniki zapalenia w organizmie rosły. Mimo to nie zmieniono antybiotyków ani nie powiedziano Dorocie prawdy. Nikt nie poinformował ani jej, ani rodziny, że szanse na uratowanie ciąży są praktycznie zerowe, a ryzyko sepsy rośnie.
Personel medyczny miał trzy doby na wdrożenie postępowania ratującego jej życie. W środę nad ranem 24 maja, gdy Dorota była już nieprzytomna, stwierdzono, że jest w stanie wstrząsu septycznego. O godz. 5.20 lekarze stwierdzili obumarcie płodu. By uratować życie Doroty, nie musieli na to czekać. Ustawa o planowaniu rodziny, ochronie płodu ludzkiego z 1993 roku, nawet po nowelizacji za sprawą wyroku pseudoTK z 2020 roku, nie nakłada na lekarzy obowiązku czekania na ustanie akcji serca u płodu.
Dorota zmarła, bo nie udzielono jej pomocy, gdy była już w stanie krytycznym. Dorota zmarła, bo lekarze wybierają postawę wyczekującą a ochrona płodu jest dla personelu medycznego ważniejsza niż zdrowie i życie osoby w ciąży.
Dziś jesteśmy myślami z rodziną i bliskimi Doroty.
Nigdy nie powinnyśmy zapomnieć i przechodzić obojętnie nad śmiercią kobiet w wyniku zakazu aborcji.
użyte zdjęcia: archiwum prywatne rodziny Doroty i zdjęcie z Agaty Kubis dla OKO.press
#aborcja #historieaborcyjne #legalnaaborcja #ciąża #bezpieczeństwo #zdrowie #kobieta #kobiety #dziewczyna #dziewczyny #ciało #szpital #medycyna #lekarze @aborcja
-
The Uprising of Mitochondrial DNA Biomarker in Cancer
Advances in predictive #diagnostic and #precisionmedicine, can lead to powerful discoveries and treatments for patients. #Cancer cells acquire functional capabilities to survive, proliferate, and circulate due to an enabling characteristic called genomic instability. Genomic maintenance systems have the ability to spot and repair any #DNA defects, while cancer cells increase the rates of mutation that orchestrate tumorigenesis. Chromosomal instability (CIN) is one of the most frequent changes observed in cancer cells, which often results from aberrations in chromosome structures and numbers. The second section of the paper focuses on #biomarkers, which are substances, structures, or processes that can influence or predict the incidence and outcome of a disease. There are three classifications of biomarkers: exposure, effect, and susceptibility. Biomarkers of exposure measure exogenous chemicals or their metabolites within an organism, while biomarkers of effect measure alterations of endogenous factors caused by exposure to an exogenous agent. Biomarkers of susceptibility measure genetic polymorphism predisposition of individuals and their external multifactorial influencers. Surrogate endpoints are often used to substitute clinical endpoints, and biomarkers can be used as a screening tool for an early indicator of #malignancy-risk development. They can also be used as diagnostic aids and prognostic biomarkers, as well as predictive biomarkers to identify the sensitivity and/or resistance of cancer patients towards specific agents or #medical product exposure.
The communication between the nucleus and mitochondria of a cell is known as intergenomic #crosstalk and it is bidirectional, meaning it can go both ways. It is important for regulating energy metabolism and tumor suppression. The communication is achieved by pathways such as anterograde #signaling and retrograde signaling. Anterograde signaling is when the nucleus controls gene transcription and cytoplasmic mRNA translation in response to external signals. Retrograde signaling is when mitochondrial dysfunction or loss of mitochondrial #membrane potential triggers communication with the nuclear genetic compartment. This communication is important for #homeostasis adaptation and can detect any nuclear damage or nuclear stress.
#Mitochondria are organelles found in cells that are responsible for producing energy. They are believed to have originated from a #singlecell-ed organism and are made up of two membranes. They contain their own genetic material, called #mtDNA, which is made up of 16569 nucleotide base pairs. mtDNA mutations can lead to mitochondrial dysfunction, which can cause #onco-genic events, such as #tumor cell reprogramming and metabolic shifts. #Mitoepigenetics is the study of how #epigenetics mechanisms regulate mtDNA transcription and replication, and it is believed to be involved in cancer progression.
The interconnection between #carcinogenesis (the development of cancer) and mitochondria (the energy-producing organelles in cells) was first proposed in 1973. Since then, there have been many studies done on this topic, using DNA scanning technologies to detect mutations and deletions. Mitochondrial DNA (mtDNA) is beneficial for carcinogenic studies because it consists of 37 genes with no introns, meaning most mutations will occur in coding regions. Additionally, mtDNA has a small size, is easy to extract, has no genetic rearrangements, and has fast mutation rates, which makes it useful for molecular research. It also has a high copy number, meaning only minimal #tissue samples are needed for analysis. Large-scale deletions are commonly known to be responsible for mitochondrial diseases, and are thought to be the cause of various diseases and cancers.
Two types of mtDNA deletions, 3.4 kb and 4977 bp are associated with various types of cancer. The 3.4 kb deletion was patented by Parr et al. [97] and is used to detect cancer in individuals. It is also used to determine different #prostate tissue types, either benign, malignant, or proximal to malignant [100]. The 4977 bp deletion is primarily associated with #aging and is a common deletion with missing mtDNA nucleotide sequences starting at 8470 to 13447 np [106]. It has been studied in various types of cancer, such as #breastcancer, #colorectal, gastric, hepatocellular, and #brain tumors, and is thought to be associated with external environmental factors, genetic predisposition, and ethnicity.
The text is discussing different types of deletions in mtDNA (mitochondrial DNA) that are associated with cancer. The 5.1.3 section is talking about the 3895 bp deletion, which was first observed in 1991 in two patients with progressive external #ophthalmoplegia. It was then found to be 10 times less frequent than the 4977 bp deletion. A study involving 104 age-matched subjects showed that the 3895 bp deletion was more frequent in those with usually sun-exposed skin and nonmelanoma skin cancer. The 4576 bp deletion was then discussed, which was found to be an indicator for breast cancer in a study involving 39 breast cancer patients. The 4576 bp deletion was not found in 23 normal patients without breast cancer. The text then moves on to discuss mtDNA copy number, which is the amount of mtDNA in each cell. It is suggested that mtDNA copy number changes may lead to mitochondrial instability and regulate energy metabolism, which can initiate #tumorigenesis. Studies have also shown that mtDNA copy number changes can be used as a predictive biomarker for #chemotherapy response.
Cell-free mtDNA (cf-mtDNA) is a type of mitochondrial DNA that is released into the #blood circulation due to disruption of the normal mitochondrial life cycle. It is believed to activate the Toll-like receptor 9 (TLR9) pathway, which can cause #inflammation and potentially lead to cancer. It has been used to diagnose cancer and sepsis, and as a biomarker for metabolic syndrome and predicting the risk of future diabetes. It is also being studied as a #noninvasive liquid #biopsy for cancer, as higher levels of cf-mtDNA have been found in cancer patients compared to healthy controls. Research is being conducted to find the potential link between cf-mtDNA and various cancers, as it is a preferable biomarker due to its higher mtDNA copy number, simpler structure, and shorter length.
Mitochondrial Microsatellite Instability (#mtMSI) is a type of genetic mutation that occurs in the mitochondrial genome. It is caused by short tandem repeats (mononucleotide or dinucleotide) of 1 to 6 base pairs that are scattered throughout the mitochondrial genome. These variations can lead to frameshift mutations, which can be caused by DNA polymerase γ, an enzyme that is responsible for oxidative damage. Mammalian mitochondria also have an inefficient mismatch repair system, which can lead to mtMSI formation. The most commonly reported mtMSI is located in the D-loop region, which is a mutational hotspot in primary tumors. It is a highly polymorphic homopolymeric C stretch, which is involved in R-loop formation, a stable RNA-DNA hybrid that triggers mtDNA replication. D310 alteration has been suggested as a new cancer detection tool and a potential early premalignant cancer marker. Another potential marker is D16184, which is located in the hypervariable region I and is involved in mtDNA biogenesis. Studies have reported the presence of D16184 in various cancer types, such as gastric and endometrial carcinoma. Somatic mtDNA alterations have also been correlated to cancer, with evidence showing that mtDNA changes can contribute to the development or progression of cancer. One example of a somatic mtDNA alteration is A12308G, which is located in the variable loop next to the anticodon stem of tRNA Leu (CUN). This alteration has been suggested as a potential diagnostic tool for #colorectalcancer and as a risk factor for prostate and #renalcancer. A10398G has also been studied in relation to cancer, although the results have been conflicting.
Mitochondrial biomarkers are molecules that can be used to detect cancer in its early stages. A commercial kit (PCMT) has been developed to help with this detection. However, even if cancer is detected early, it can still be difficult to treat if the symptoms have not yet developed. Therefore, researchers are looking into gene therapy and other mitochondrial interventions as potential treatments for cancer. They can use current advancements in vitro mitochondrial intervention to identify the pathogenicity and therapeutic potential of a particular mtDNA mutation. One method proposed is to transfer artificial healthy mitochondria to remove damaged mtDNA without genetic manipulation. Other studies have looked at the levels of mtDNA biomarkers in cancerous and non-cancerous samples, as well as the levels of mtDNA methylation and mtRNA in cancerous tissues.
