Search
23 results for “SjorsScheres”
-
This is fantastic to hear! 🥳 The next version, #ModelAngelo 1.0, will be even better at this than the current version.
---
RT @Kaelberviridae
@SjorsScheres @jamaliki1998 We recently discovered a novel virus by cryoEM. Although we figured out its relatives by manual inspection of the map, today we retrospectively analyzed it with #ModelAngelo and indeed this was as effective as next-gen sequencing in determining the closest relative
https://twitter.com/Kaelberviridae/status/1630331496405008384 -
#OpenSoftwareAcceleratesScience! 😍
---
RT @ribo_rob
Happy to share @cryocloud_io's first blog article & benchmark! Huge thanks to @SjorsScheres for making #Relion #opensource, & @RadoDanev for uploading the data to #Empiar - this would not have been possible otherwise!
#cryoEM #cloudcomputing https://twitter.com/cryocloud_io/status/1621094105492369408
https://twitter.com/ribo_rob/status/1621094951596564480 -
Ok, let's try this out. An also on Twitter @SjorsScheres, but worried about recent developments there, and liking the #opensource and distributed nature of Mastodon. Do have a look at our own open software #RELION (relion.readthedocs.io) for #cryoEM structure determination of proteins.
-
Finally got around to trying #modelangelo - wow.
Three chains build into a boxed asymmetric unit of a virus capsid resolved to 2.5 angstroms. Some minor tinkering to get to a pretty comprehensive and accurate model ready for refinement - and fast. Thanks @SjorsScheres -
Read tomorrow's Nature to find out what we think 7 years of solving #cryoEM structures of brain-derived #amyloids has taught us about neurodegeneration, and where to go from here. With Michel Goedert and Ben Ryskeldi-Falcon; very grateful to present and past group members.
https://rdcu.be/dnaXd -
I can highly recommend @WenjuanZhang11: she is a fantastic scientist and a wonderful person. Work with her on #cryoEM of yeast #amyloids!
---
RT @WenjuanZhang11
We are recruiting a #postdoc to join our team @MRC_Prion at @ucl for studying #CryoEM structures of prion-like protein assemblies in neurodegenerative diseases and yeast model. More information and apply link are here: http://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details…
https://twitter.com/WenjuanZhang11/status/1630577935831662593 -
The identity of extra densities in #cryoEM maps of #amyloids from brains remains unknown, and a major focus of research. Just because a model fits in these fuzzy densities does not mean much, and writing speculative papers is going to be of little help.
https://www.biorxiv.org/content/10.1101/2023.02.01.526613v1 -
Good stuff from the Steen lab! @ionicwoman
---
RT @ionicwoman
Kathrin Wenger and our team asked, Why do drugs for Alzheimer’s Disease work in animal models, but often fail in clinical trials?
https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00601-y
#AlzheimersDisease #tauopathy #proteomics #HarvardMed #neurodegeneration #dementia
https://twitter.com/ionicwoman/status/1621281689896103936 -
😍🤯
---
RT @MaxGemmer
Very happy to share our recent work on protein biogenesis at the ER membrane. We analyzed 150,000 ribosomes from 1000+ tomograms of ER-derived vesicles to visualize ribosome intermediates and their downstream translocon machinery.
1/#TeamTomo #CryoEM
https://www.nature.com/articles/s41586-022-05638-5
https://twitter.com/MaxGemmer/status/1618495422988947457 -
Just in case this leads to the suspension of my account, 👋#goodbye! I get most of my science (#cryoEM, #amyloids, #Alzheimers) and other news here; and am 🥰 grateful to my 12.5k followers for their interest. I would miss this all dearly, but there are limits...
-
And below shows the improvement in the reconstruction (coloured per local resolution) from standard #RELION (left) to Johannes' method (right).
-
We plan to include this functionality in #RELION-4.1, with its beta-release scheduled for mid-2023. At the moment, we are writing a paper describing the method in detail and are working hard on making the code as easy to use and install as you are used to.
-
By @jgreener64 and @jamaliki1998 (also #ModelAngelo): fast protein searches using graph embeddings! 🥳
https://www.biorxiv.org/content/10.1101/2022.11.28.518224v1 -
Just a reminder for those struggling with #amyloid reconstruction in #relion that we recently wrote a tutorial-like paper on this in @Faraday_D, which comes with publicly available data sets at @EMDB_EMPIAR.
https://pubs.rsc.org/en/content/articlelanding/2022/FD/D2FD00034B
-
Pretty happy today to have found a bug in my new subtomogram averaging #teamtomo code that had been messing up results for months now! 🥳
-
A fantastic recognition of these amazing scientists' contributions! 🥳
---
RT @MRC_LMB
Congratulations to @KellyTHD_Nguyen, @bwfalcon and LMB alumni, @BolandLab_GE and @M_Hospenthal, for being elected @EMBO_YIP!Read the full news story here: https://www2.mrc-lmb.cam.ac.uk/embo-announces-2023-elections-for-young-investigator-programme/
#LMBNews #LMBAlumni #telomeres #DNAreplication #neurodegenerative #diseases
https://twitter.com/MRC_LMB/status/1595060285261373443 -
A fantastic recognition of these amazing scientists' contributions! 🥳
---
RT @MRC_LMB
Congratulations to @KellyTHD_Nguyen, @bwfalcon and LMB alumni, @BolandLab_GE and @M_Hospenthal, for being elected @EMBO_YIP!Read the full news story here: https://www2.mrc-lmb.cam.ac.uk/embo-announces-2023-elections-for-young-investigator-programme/
#LMBNews #LMBAlumni #telomeres #DNAreplication #neurodegenerative #diseases
https://twitter.com/MRC_LMB/status/1595060285261373443 -
A fantastic recognition of these amazing scientists' contributions! 🥳
---
RT @MRC_LMB
Congratulations to @KellyTHD_Nguyen, @bwfalcon and LMB alumni, @BolandLab_GE and @M_Hospenthal, for being elected @EMBO_YIP!Read the full news story here: https://www2.mrc-lmb.cam.ac.uk/embo-announces-2023-elections-for-young-investigator-programme/
#LMBNews #LMBAlumni #telomeres #DNAreplication #neurodegenerative #diseases
https://twitter.com/MRC_LMB/status/1595060285261373443 -
A fantastic recognition of these amazing scientists' contributions! 🥳
---
RT @MRC_LMB
Congratulations to @KellyTHD_Nguyen, @bwfalcon and LMB alumni, @BolandLab_GE and @M_Hospenthal, for being elected @EMBO_YIP!Read the full news story here: https://www2.mrc-lmb.cam.ac.uk/embo-announces-2023-elections-for-young-investigator-programme/
#LMBNews #LMBAlumni #telomeres #DNAreplication #neurodegenerative #diseases
https://twitter.com/MRC_LMB/status/1595060285261373443 -
A fantastic recognition of these amazing scientists' contributions! 🥳
---
RT @MRC_LMB
Congratulations to @KellyTHD_Nguyen, @bwfalcon and LMB alumni, @BolandLab_GE and @M_Hospenthal, for being elected @EMBO_YIP!Read the full news story here: https://www2.mrc-lmb.cam.ac.uk/embo-announces-2023-elections-for-young-investigator-programme/
#LMBNews #LMBAlumni #telomeres #DNAreplication #neurodegenerative #diseases
https://twitter.com/MRC_LMB/status/1595060285261373443